PDGFB Antibody

Datasheet
Code CSB-PA153276
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P01127
Image
  • Western blot analysis of extracts from NIH/3T3 cells, using PDGFB antibody.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthesized peptide derived from Human PDGFB.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous levels of total PDGFB protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA By similarity.

Li Fang, Arterioscler. Thromb. Vasc. Biol., Apr 2004; 24: 787 - 792.
EJ Battegay, J. Cell Biol., May 1994; 125: 917.
RA Seifert, J. Biol. Chem., Feb 1993; 268: 4473 - 4480.
Jason Liu, Am J Physiol Lung Cell Mol Physiol, May 1998; 274: 702.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias PDGF2; ONCOGENE SIS; PDGF B CHAIN; PLATELET-DERIVED GROWTH FACTOR B CHAIN; SIMIAN SARCOMA VIRAL ONCOGENE HOMOLOG
Immunogen Species Homo sapiens (Human)
Target Names PDGFB
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin
Involvement in disease Basal ganglia calcification, idiopathic, 5 (IBGC5)
Subcellular Location Secreted
Protein Families PDGF/VEGF growth factor family
Tissue Specificity Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Database Links

HGNC: 8800

OMIM: 190040

KEGG: hsa:5155

STRING: 9606.ENSP00000330382

UniGene: Hs.1976

Pathway Jak-STAT signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Ras signaling pathway
Phospholipase D signaling pathway
Rap1 signaling pathway

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