PDGFB

PDGFB encodes the Platelet - derived growth factor subunit B. It is also commonly known as PDGF - 2. This protein is crucial in cell growth, division, and blood vessel formation. It functions by binding to its receptor, PDGFR - β, initiating a cascade of intracellular signaling events. The pathways involved include the PI3K - AKT and MAPK pathways.
Abnormal expression of PDGFB is linked to various diseases, such as glioblastoma and pulmonary hypertension. In drug development, several inhibitors targeting the PDGFR - β pathway are being investigated. These drugs aim to block the excessive signaling caused by PDGFB overexpression, offering potential new treatments for related diseases.