Recombinant Human Interleukin-17A protein(IL17A) (Active)


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Code CSB-AP001851HU
Product Type Interleukin
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Uniprot No. Q16552
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IL-17, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of >1.3x105 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA
Research Area Immunology
Source E.Coli
Gene Names IL17A
Expression Region 24-155aa
Tag Info Tag-Free
Mol. Weight 31.0 kDa
Protein Description Full Length of Mature Protein
PubMed ID 8676080; 7499828; 14574404; 15489334; 15340161; 19835883
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Function Ligand for IL17RA and IL17RC
Subcellular Location Secreted
Protein Families IL-17 family
Tissue Specificity Restricted to activated memory T-cells.
Database Links

HGNC: 5981

OMIM: 603149

KEGG: hsa:3605

STRING: 9606.ENSP00000344192

UniGene: Hs.41724

Pathway IL-17 signaling pathway
Th17 cell differentiation

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