|Have Questions?||Leave a Message or Start an on-line Chat|
The production of the IL17A monoclonal antibody started by using recombinant human IL17A protein as an immunogen. The cDNA of IL17A monoclonal antibody was sequenced and the gene was cloned into a plasmid vector. The plasmid vector containing the IL17A monoclonal antibody gene was then transfected into a host cell using a suitable transfection method. The resulting IL17A recombinant monoclonal antibody was purified using affinity chromatography and its specificity was tested using ELISA. It only reacts with human IL17A protein. It was found to bind specifically to the recombinant human IL17A(CSB-BP624104HU(M)) with an EC50 range of 1.818-2.170 ng/mL.
IL17A is a cytokine protein produced by various immune cells, including T helper 17 (Th17) cells and other cell types such as γδ T cells, natural killer (NK) T cells, and some innate lymphoid cells. The main function of IL-17A is to induce inflammatory responses, particularly in the context of defense against bacterial and fungal infections. It promotes the recruitment and activation of neutrophils and other immune cells to sites of infection, as well as the production of pro-inflammatory cytokines and chemokines. IL-17A has also been implicated in the pathogenesis of several autoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, and psoriasis.
There are currently no reviews for this product.