Recombinant Human Interleukin-31 protein(IL31) (Active)

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Code CSB-AP001901HU
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q6EBC2
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH7.4 ,lyophilized
Alias IL-31
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5 ng/mL of rHuIL-31 can effectively induce STAT3 activation.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Research Area Immunology
Source E.coli
Gene Names IL31
Expression Region 24-164aa
Tag Info Tag-Free
Mol. Weight 15.8 kDa
Protein Description Full Length of Mature Protein
PubMed ID 15184896; 15489334; 16461143; 17030248
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Function Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR
Subcellular Location Secreted
Tissue Specificity Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Database Links

HGNC: 19372

OMIM: 609509

KEGG: hsa:386653

STRING: 9606.ENSP00000366234

UniGene: Hs.569071

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