Recombinant Mouse Interleukin-10 protein(Il10) (Active)

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Code CSB-AP003351MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
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Uniprot No. P18893
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IL-10, CSIF
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine MC/9-2 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SRGQYSREDN NCTHFPVGQS HMLLELRTAF SQVKTFFQTK DQLDNILLTD SLMQDFKGYL GCQALSEMIQ FYLVEVMPQA EKHGPEIKEH LNSLGEKLKT LRMRLRRCHR FLPCENKSKA VEQVKSDFNK LQDQGVYKAM NEFDIFINCI EAYMMIKMKS
Research Area Immunology
Source E.coli
Gene Names Il10
Expression Region 19-178aa
Tag Info Tag-Free
Mol. Weight 18.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 2161559; 1350294; 19468303; 15489334; 8364028
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Function Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Subcellular Location Secreted
Protein Families IL-10 family
Database Links

KEGG: mmu:16153

STRING: 10090.ENSMUSP00000016673

UniGene: Mm.874

Pathway Jak-STAT signaling pathway
T cell receptor signaling pathway
FoxO signaling pathway

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