CASP8 Monoclonal Antibody

Datasheet
Code CSB-MA080171
Product Type Monoclonal Antibody
Size US$167
Uniprot No. Q14790
Image
  • Immunohistochemical analysis of paraffin-embedded Mouse Spleen Tissue using Caspase-8 Monoclonal Antibody.

  • Western blot analysis of 1) Hela, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using Caspase-8 Monoclonal Antibody.

Immunogen Recombinant Protein
Raised in Mouse
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Isotype IgG
Alias Caspase-8
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Gene Names CASP8
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Involvement in disease Caspase-8 deficiency (CASP8D)
Subcellular Location Cytoplasm
Protein Families Peptidase C14A family
Tissue Specificity Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
Database Links

HGNC: 1509

OMIM: 211980

KEGG: hsa:841

STRING: 9606.ENSP00000351273

UniGene: Hs.599762

Pathway p53 signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
IL-17 signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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