CASP8

Caspase-8 is a protein in humans that is encoded by CASP8 gene. Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.

CASP8 Antibodies

CASP8 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA18109B0Rb CASP8 Antibody, HRP conjugated Human ELISA
CSB-PA18109C0Rb CASP8 Antibody, FITC conjugated Human ELISA
CSB-PA004553GA01HU CASP8 Antibody Human ELISA,WB,IHC
CSB-PA18109D0Rb CASP8 Antibody, Biotin conjugated Human ELISA
CSB-PA982156 CASP8 Antibody Human ELISA,WB
CSB-PA000009 Cleaved-CASP8 (D384) Antibody Human WB,IHC,IF,ELISA
CSB-PA000653 Phospho-CASP8 (Y380) Antibody Human WB,ELISA
CSB-PA001234 CASP8 Antibody Human,Mouse,Rat WB,IHC,ELISA
CSB-PA060299 Phospho-CASP8 (S347) Antibody Human,Rat WB,IHC,ELISA
CSB-MA080171 CASP8 Monoclonal Antibody Human,Mouse,Rat ELISA,WB,IHC
CSB-PA080234 CASP8 Antibody Human,Mouse,Rat WB,IHC

CASP8 Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA18109A0Rb CASP8 Antibody Human ELISA, WB, IHC, IF

CASP8 Proteins

CASP8 Proteins for Mus musculus (Mouse)

Code Product Name Source
CSB-YP004553MO Recombinant Mouse Caspase-8(Casp8),Yeast Yeast
CSB-EP004553MO Recombinant Mouse Caspase-8(Casp8),Escherichia Coli E.coli
CSB-BP004553MO Recombinant Mouse Caspase-8(Casp8),Baculovirus Baculovirus
CSB-MP004553MO Recombinant Mouse Caspase-8(Casp8),Mammalian cell Mammalian cell

CASP8 Proteins for Homo sapiens (Human)

Code Product Name Source
CSB-YP621791HU Recombinant Human Caspase-8(CASP8),partial,Yeast Yeast
CSB-EP621791HU Recombinant Human Caspase-8(CASP8),partial,Escherichia Coli E.coli
CSB-BP621791HU Recombinant Human Caspase-8(CASP8),partial,Baculovirus Baculovirus
CSB-MP621791HU Recombinant Human Caspase-8(CASP8),partial,Mammalian cell Mammalian cell
CSB-RP181094h(A3) Recombinant Human Caspase-8(CASP8),partial E.coli

CASP8 cDNA

CASP8 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL621791HU1 CASP8 pUC NM_001080124.1
CSB-CL621791HU2 CASP8 pUC NM_001080125.1
CSB-CL621791HU3 CASP8 pUC NM_001228.4
CSB-CL621791HU4 CASP8 pUC NM_033355.3
CSB-CL621791HU5 CASP8 pUC NM_033356.3
CSB-CL621791HU6 CASP8 pUC NM_033358.3

CASP8 ELISA Kit

CASP8 ELISA Kit for Homo sapiens (Human)

Code Product Name Sample Types Sensitivity
CSB-E13636h Human Caspase 8(Casp-8) ELISA Kit serum, plasma, cell lysates 7.8 pg/mL

CASP8 ELISA Kit for Mus musculus (Mouse)

Code Product Name Sample Types Sensitivity
CSB-EL004553MO Mouse Caspase-8(CASP8) ELISA kit serum, plasma, tissue homogenates, cell lysates 11.7 pg/mL

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