CASP8

Caspase-8 is a protein in humans that is encoded by CASP8 gene. Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.

CASP8 Antibodies

CASP8 Antibodies for Homo sapiens (Human)

CASP8 Antibodies for Human

CASP8 Proteins

CASP8 Proteins for Mus musculus (Mouse)

CASP8 Proteins for Homo sapiens (Human)

CASP8 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL621791HU1 CASP8 pUC NM_001080124.1
CSB-CL621791HU2 CASP8 pUC NM_001080125.1
CSB-CL621791HU3 CASP8 pUC NM_001228.4
CSB-CL621791HU4 CASP8 pUC NM_033355.3
CSB-CL621791HU5 CASP8 pUC NM_033356.3
CSB-CL621791HU6 CASP8 pUC NM_033358.3

CASP8 ELISA Kit

CASP8 ELISA Kit for Homo sapiens (Human)

CASP8 ELISA Kit for Mus musculus (Mouse)

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