ATP1B1 Antibody

Code CSB-PA002326LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, Rat heart tissue, Mouse heart tissue
    All lanes: ATP1B1 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 36, 35 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA002326LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA002326LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA002326LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ATP1B1 Polyclonal antibody
Uniprot No.
Target Names
ATP1B1
Alternative Names
ATP1B1; ATP1B; Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1
Raised in
Rabbit
Species Reactivity
Human, Rat, Mouse
Immunogen
Recombinant Human Sodium/potassium-transporting ATPase subunit beta-1 protein (64-241AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ATP1B1 Antibody (Product code: CSB-PA002326LA01HU) is Non-conjugated. For ATP1B1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA002326LB01HU ATP1B1 Antibody, HRP conjugated ELISA
FITC CSB-PA002326LC01HU ATP1B1 Antibody, FITC conjugated
Biotin CSB-PA002326LD01HU ATP1B1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

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Target Background

Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.; Involved in cell adhesion and establishing epithelial cell polarity.
Gene References into Functions
  1. Novel Single Nucleotide Polymorphism at ATP1B1 implicate gene regulatory dysfunction in QT prolongation in African and Hispanic Americans. PMID: 27988371
  2. the ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion. PMID: 27142834
  3. Our study describes the potent inhibition of Chikungunya virus and related alphaviruses by the cardiac glycoside digoxin and demonstrates a function for the sodium-potassium ATPase in Chikungunya virus infection. PMID: 27222471
  4. Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues. PMID: 27515006
  5. Overexpression of ATP1B1 is associated with cytogenetically normal acute myeloid leukemia. PMID: 26506237
  6. Na,K-ATPase b1-subunit is a target of the Shh signaling pathway and loss of b1-subunit expression may contribute to tumor development and progression not only in carcinoma but also in medulloblastoma, a tumor of neuronal origin. PMID: 26286140
  7. Impaired regulation and compromised activity of ion channel proteins contribute to the pathophysiology of vascular dementia. PMID: 25152327
  8. Activities of AE1 and the sodium pump are coregulated in kidney. PMID: 25012180
  9. ATP1B1 is epigenetically silenced by promoter methylation in both renal cell carcinoma (RCC) patients' tissues and cell lines. PMID: 24452105
  10. A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PMID: 24098465
  11. Changes were found in mRNA and protein expressions of Na(+)/K(+)-ATPase subunits in LG from term pregnant rabbits and these changes suggest a role in the pregnancy-related LG secretion changes and dry eye symptoms observed in these animals. PMID: 23009595
  12. Data show that protein kinase A (PKA) phosphorylation has a drastic impact on Na(+)/K(+)-ATPase (NKA) structure and dynamics PMID: 22433860
  13. examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans PMID: 21881522
  14. interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions PMID: 21642423
  15. Na(+)-K(+) ATPase B1 can synergize with adriamycin and reverse drug resistance in MCF7 cells. PMID: 19664334
  16. Silencing of ATP1B1 gene can enhance the proliferation and migration capability of SGC-7901 adenocarcinoma cells. PMID: 19619434
  17. through its interaction with ATP1B1, MLC1 is involved in the control of intracellular osmotic conditions and volume regulation in astrocytes, opening new perspectives for understanding the pathological mechanisms of MLC disease. PMID: 20926452
  18. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
  19. Results identified that the beta1 subunit of the host Na(+)/K(+)-ATPase beta1 subunit (ATP1B1) interacts with the cytoplasmic domain of both the influenza A and B virus M2 and BM2 proteins. PMID: 21104370
  20. Data show that deglycosylation in polarized hepatic cells by drugs, or by site-directed mutagenesis of the N-linked-glycosylation residues, cause the Na+/K+-ATPase beta-subunit to traffic from the native basolateral to the apical/canalicular domain. PMID: 16339171
  21. these studies are indicative of a synergism between Sp1 and CREB in mediating regulation of Na-K ATPase beta1 subunit by PGRE3; while regulation occurring through PGRE1 also involves Sp1 and CREB. PMID: 16478973
  22. Study identifies an interaction between Wolframin and Na+/K+ ATPase beta1 subunit in transfected Cos7 cells, and between endogenous proteins in placental, neuroblastoma and MIN6 pancreatic beta-cell lines. PMID: 17947299
  23. E2A and Na/K-ATPase beta1 subunit expression in epithelial cells are regulated by interactions between these proteins. PMID: 18727914
  24. Reduced expression of the Na,K-beta(1) protein is associated with oxaliplatin resistance in cancer cells. PMID: 19322565
  25. Propose that kinase-dependent regulation of the Na(+)-K(+) pump occurs via glutathionylation of its beta(1) subunit (ATP1B1) at Cys46. PMID: 19542013
  26. ATP1B1 may confer susceptibility to BP regulation and hypertension in this Chinese population. PMID: 19563793
  27. Measured properties of the purified carboxy-terminal lobe suggest that the fragment is correctly folded and compatible with the proposed model of Na,K-ATPase beta1 subunit. PMID: 19694409
  28. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19305409

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Subcellular Location
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell membrane, sarcolemma.
Protein Families
X(+)/potassium ATPases subunit beta family
Tissue Specificity
Found in most tissues.
Database Links

HGNC: 804

OMIM: 182330

KEGG: hsa:481

STRING: 9606.ENSP00000356789

UniGene: Hs.291196

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