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| Code | CSB-PA223208 |
| Size | US$299 |
| Uniprot No. | Q07817 |
| Image |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol |
| Immunogen | Fusion protein of Human BCL2L1 |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000 |
| Relevance | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method | Antigen affinity purification |
| Isotype | IgG |
| Alias | Bcl-2-like protein 1 |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | BCL2L1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION |
| Subcellular Location | Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side |
| Protein Families | Bcl-2 family |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Database Links |
HGNC: 992 OMIM: 600039 KEGG: hsa:598 STRING: 9606.ENSP00000302564 UniGene: Hs.516966 |
| Pathway |
Jak-STAT signaling pathway
PI3K-Akt signaling pathway NF-kappa B signaling pathway Apoptosis Autophagy Ras signaling pathway NOD-like receptor signaling pathway |
BCL2L1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-MA0026131A0m | BCL2L1 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-PA002613KA01HU | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA027199GA01HU | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002613HB01HU | BCL2L1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002613HC01HU | BCL2L1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA002613HD01HU | BCL2L1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA923588 | BCL2L1 (Ab-62) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000986 | BCL2L1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA000987 | BCL2L1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040205 | Phospho-BCL2L1 (S62) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040206 | Phospho-BCL2L1 (T47) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA040207 | Phospho-BCL2L1 (T115) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA040208 | BCL2L1 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA080279 | BCL2L1 Antibody | Human,Mouse,Rat | IHC |
| CSB-PA315068 | BCL2L1 Antibody | Human,Mouse,Rat | ELISA,WB |
BCL2L1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002613HA01HU | BCL2L1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
BCL2L1 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA786016 | Phospho-BCL2L1 (Ser62) Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
BCL2L1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP002613HU | Recombinant Human Bcl-2-like protein 1(BCL2L1),partial | E.coli |
| CSB-YP002613HU CSB-BP002613HU CSB-MP002613HU |
Recombinant human Bcl-2-like protein 1 | Yeast Baculovirus Mammalian cell |
BCL2L1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL002613HU | Human Bcl-2-like protein 1(BCL2L1) ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
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Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K23) Antibody
Applications: ELISA, WB, IF, ChIP
Species Reactivity: Human
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