CASP9 Antibody

Datasheet
Code CSB-PA785649
Size US$299
Uniprot No. P55211
Image
  • The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA785649(CASP9 Antibody) at dilution 1/70. (Original magnification: ×200)
  • The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA785649(CASP9 Antibody) at dilution 1/70. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Hela cells, Mouse liver tissue,Primary antibody: CSB-PA785649(CASP9 Antibody) at dilution 1/750 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human CASP9
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB,IHC;ELISA:1:2000-1:5000,WB:1:500-1:2000,IHC:1:100-1:300
Relevance This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias Caspase-9
Immunogen Species Homo sapiens (Human)
Target Names CASP9
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION
Protein Families Peptidase C14A family
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Database Links

HGNC: 1511

OMIM: 602234

KEGG: hsa:842

STRING: 9606.ENSP00000330237

UniGene: Hs.329502

Pathway p53 signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Apoptosis

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