CXCR4 Antibody

Datasheet
Code CSB-PA263860
Size US$299
Uniprot No. P61073
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA263860(CXCR4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA263860(CXCR4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human CXCR4
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:2000-1:5000,IHC:1:50-1:200
Relevance This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias chemokine (C-X-C motif) receptor 4
Immunogen Species Homo sapiens (Human)
Target Names CXCR4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Involvement in disease WHIM syndrome (WHIMS)
Subcellular Location Cell membrane, Multi-pass membrane protein, Cell junction, Early endosome, Late endosome, Lysosome
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microv
Database Links

HGNC: 2561

OMIM: 162643

KEGG: hsa:7852

STRING: 9606.ENSP00000386884

UniGene: Hs.593413

Pathway Chemokine signaling pathway
Leukocyte transendothelial migration
Endocytosis

Related Products

CXCR4 Antibodies

CXCR4 Antibodies for Homo sapiens (Human)

CXCR4 Antibodies for Human

CXCR4 Proteins

CXCR4 Proteins for Homo sapiens (Human)

CXCR4 Proteins for Homo sapiens (Human)

CXCR4 ELISA Kit

CXCR4 ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.