CXCR4

The C X C chemokine receptor 4 (CXCR4) belongs to G protein-coupled receptor (GPCR) family with a conserved 7 transmembrane (7TM) protein structure. At present, GPCRs superfamily provides many desirable therapeutic targets in cancer and other diseases.

CXCR4 is expressed by most cells, including hematopoietic and endothelial cells (ECs), neurons and stem cells (embryonic and adult). Additionally, CXCR4 has been discovered strongly expressed in multiple types of cancers and take effects on angiogenesis, cell metastasis, growth or survival. Moreover, CXCR4 is also involved in HIV virus infection. These biological functions supports that CXCR4 could be potentially an ideal target for tumors, hematopoietic stem cell mobilization, HIV and other diseases.

So how's the mechanism of CXCR4 in tumors? CXCR4 specifically binds to its ligand CXCL12 to activate a series of downstream signaling pathways, which in turn regulate biological behaviors such as cell survival, proliferation, migration and adhesion in tumors. CXCR4-CXCL12 is involved in activating a variety of pro-oncogenic pathways that promote cell proliferation, inhibit apoptosis, and promote metastasis, including signaling pathways RAS-MAPK-MEK1/2, ERK1/2, PI3K-AKT and NF-kB.

Validated Data

antigen-antibody binding determined
by WB

CSB-MP006254HU(F1) is detected by Mouse anti-6*His monoclonal antibody.

The binding activity of antigen-antibody validated by functional ELISA

Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC₅₀ is 101.7-253.6 ng/mL.

The following CXCR4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CXCR4 Antibodies

CXCR4 Proteins

CXCR4 ELISA Kits

CXCR4 Antibodies

CXCR4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006254GA01HU	CXCR4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002588	CXCR4 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-PA060127	Phospho-CXCR4 (S339) Antibody	Human,Mouse,Rat,Monkey	WB, IHC, IF, ELISA
CSB-PA006254YD01HU	CXCR4 Antibody, Biotin conjugated	Human	ELISA
CSB-PA006254YC01HU	CXCR4 Antibody, FITC conjugated	Human
CSB-PA006254YB01HU	CXCR4 Antibody, HRP conjugated	Human	ELISA
CSB-PA006254YA01HU	CXCR4 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA263860	CXCR4 Antibody	Human	ELISA,IHC
CSB-PA996565	CXCR4 Antibody	Human	ELISA,IHC
CSB-PA250029	CXCR4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA099227	CXCR4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA569311A0HU	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-RA006254MA01HU	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA

CXCR4 Proteins

CXCR4 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF638935SH	Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP638935SH1 CSB-EP638935SH1 CSB-BP638935SH1 CSB-MP638935SH1 CSB-EP638935SH1-B	Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF006254HU	Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-EP006254HU1	Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial	E.coli
CSB-EP006254HU1e0	Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial	E.coli
CSB-MP006254HU	Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs	Mammalian cell
CSB-MP006254HU(F1)	Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs (Active)	Mammalian cell

CXCR4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF006254RA	Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4)	in vitro E.coli expression system
CSB-YP006254RA1 CSB-EP006254RA1 CSB-BP006254RA1 CSB-MP006254RA1 CSB-EP006254RA1-B	Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-CF630683MOV	Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP630683MOV1 CSB-EP630683MOV1 CSB-BP630683MOV1 CSB-MP630683MOV1 CSB-EP630683MOV1-B	Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Tupaia chinensis (Chinese tree shrew)

Code	Product Name	Source
CSB-CF768744TDAE	Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP768744TDAE1 CSB-EP768744TDAE1 CSB-BP768744TDAE1 CSB-MP768744TDAE1 CSB-EP768744TDAE1-B	Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Saimiri sciureus (Common squirrel monkey)

Code	Product Name	Source
CSB-CF810237SWD	Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP810237SWD1 CSB-EP810237SWD1 CSB-BP810237SWD1 CSB-MP810237SWD1 CSB-EP810237SWD1-B	Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

Code	Product Name	Source
CSB-CF818191CYL	Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP818191CYL1 CSB-EP818191CYL1 CSB-BP818191CYL1 CSB-MP818191CYL1 CSB-EP818191CYL1-B	Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

Code	Product Name	Source
CSB-CF886927DSU	Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP886927DSU1 CSB-EP886927DSU1 CSB-BP886927DSU1 CSB-MP886927DSU1 CSB-EP886927DSU1-B	Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF006254MOW	Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254MOW1 CSB-EP006254MOW1 CSB-BP006254MOW1 CSB-MP006254MOW1 CSB-EP006254MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Papio anubis (Olive baboon)

Code	Product Name	Source
CSB-CF006254ERI	Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254ERI1 CSB-EP006254ERI1 CSB-BP006254ERI1 CSB-MP006254ERI1 CSB-EP006254ERI1-B	Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF006254EQV	Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254EQV1 CSB-EP006254EQV1 CSB-BP006254EQV1 CSB-MP006254EQV1 CSB-EP006254EQV1-B	Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

Code	Product Name	Source
CSB-CF006254DRI	Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254DRI1 CSB-EP006254DRI1 CSB-BP006254DRI1 CSB-MP006254DRI1 CSB-EP006254DRI1-B	Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF668610DO	Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP668610DO1 CSB-EP668610DO1 CSB-BP668610DO1 CSB-MP668610DO1 CSB-EP668610DO1-B	Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF755226PI	Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP755226PI1 CSB-EP755226PI1 CSB-BP755226PI1 CSB-MP755226PI1 CSB-EP755226PI1-B	Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF006254BO	Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254BO1 CSB-EP006254BO1 CSB-BP006254BO1 CSB-MP006254BO1 CSB-EP006254BO1-B	Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF006254CA	Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4)	in vitro E.coli expression system
CSB-YP006254CA1 CSB-EP006254CA1 CSB-BP006254CA1 CSB-MP006254CA1 CSB-EP006254CA1-B	Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCR4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF006254MO	Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4)	in vitro E.coli expression system
CSB-YP006254MO1 CSB-EP006254MO1 CSB-BP006254MO1 CSB-MP006254MO1 CSB-EP006254MO1-B	Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli