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To produce recombinant Human CXCR4 protein, a well-established recombinant DNA technology is the key. A DNA template of CXCR4 was constructed with N-terminal 10xHis-SUMO tag & C-terminal Myc tag using the technique. Once the template was made, the recombinant Human CXCR4 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 303-352aa of the Human CXCR4. The purity of this recombinant is 90% determined by SDS-PAGE.
CXCR4 is a protein coding gene that encodes C-X-C chemokine receptor type 4 (CD_antigen: CD184). According to some studies, CXCR4 may have the following features.
The role of CXCR4 in various diseases, including cancer and WHIM syndrome. CXCR4 expression in cancer metastases appears to be due to receptor dysregulation leading to enhanced signaling. CXCR4 regulates the growth of primary and metastatic breast cancer. CXCR4 is a prognostic marker for acute myeloid leukemia. CXCR4 plays major roles in embryonic development, homeostasis and inflammation. CXCR4 plays a key role in the crosstalk between tumor cells and their respective microenvironments, suggesting that CXCR4-targeted therapeutic approaches may become clinically important in the near future. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
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