CLDN1 Antibody

1. the accumulation and toxicity of doxorubicin were rescued by CLDN1 siRNA in A549R cells. We suggest that CLDN1 is upregulated by CDDP resistance through activation of a PI3K/Akt/NF-kappaB pathway, resulting in the inhibition of penetration of anticancer drugs into the inner area of spheroids PMID: 29524521
2. Our data indicate that CLDN1 targeting with an anti-CLDN1 mAb results in decreased growth and survival of CRC cells. This suggests that CLDN1 could be a new potential therapeutic target. PMID: 28659146
3. Human Growth Hormone Inhibits CLAUDIN-1 Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3). PMID: 28617312
4. CLDN1 promotes invasion and metastasis in cervical cancer cells via the expression of EMT/invasion-related genes. PMID: 27974683
5. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
6. Rab25 is amplified and enhances aggressiveness in luminal B cancers while in claudin-low tumors, Rab25 is lost indicating possible anti-tumor functions PMID: 27259233
7. association of genetic polymorphisms of claudin-1 with small vessel vascular dementia PMID: 28273404
8. Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome. PMID: 25972430
9. CLDN-1 promoted the migration and EMT through the Notch signaling pathway. PMID: 28316062
10. In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3. PMID: 28126724
11. Data show that miR-30a could bind to the 3'-untranslted region of Slug mRNA and increased expression of claudins, a family of tight junction transmembrane proteins. PMID: 26918943
12. These findings indicate a previously unrecognized mechanism that miR-142-5p, targeting CLDN1, plays an important role in Hashimoto's thyroiditis pathogenesis. PMID: 27277258
13. Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system. PMID: 28679754
14. Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells. PMID: 27436828
15. Increased expression of intestinal epithelial claudin-1 with downregulation of claudin-3 has been observed in intestinal inflammatory disorders. PMID: 28493289
16. Studies indicate claudin 1 (CLDN-1) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics. PMID: 28415141
17. Data show that the charge of Lys65 in claudin 1 (Cldn1) and Glu158 in claudin 3 (Cldn3), and of Gln57 in claudin 5 (Cldn5) are necessary for tight junction (TJ) strand formation. PMID: 28415153
18. Studies indicate that claudin-1 accumulate in early endosomes in both epithelial and endothelial cells. PMID: 28415156
19. Claudin-low tumors were associated with young age of onset, higher tumor grade, larger tumor size, extensive lymphocytic infiltrate and a circumscribed tumor margin. Patients with claudin-low tumors had a worse overall survival when compared to patients with luminal A type breast cancer. PMID: 28045912
20. These results revealed that CLDN1 contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies. PMID: 28651932
21. Data suggest that epithelial-mesenchymal transition (EMT) is regulated by ZMYND8 (receptor for activated protein kinase C) which selectively activates gene promoters of CLDN1 (claudin 1) and CDH1 (E-cadherin) in breast cancer cells; thus, the presence of ZMYND8 could be implicated in maintaining epithelial phenotype of cells; ZMYND8 regulates invasion/migration of breast cancer cells. PMID: 28432260
22. The data suggested that miR-29a may regulate tumor growth and migration by targeting CLDN1. PMID: 28342862
23. TNF-alpha mediated regulation of claudin-1 and tumorigenic abilities of colon cancer cells. PMID: 27742576
24. CLDN1 is significantly hypomethylated in tumor samples and that the membrane staining intensity for claudin 1, 4, and 7 is significantly lower in colorectal cancer tissues than in adjacent nonneoplastic tissue. PMID: 28381183
25. CLDN1 rather than variants in FLG may be involved in the susceptibility of AD in the Ethiopian population PMID: 27581203
26. CLDN1 overexpression is a good prognostic factor in NSCLC. PMID: 27687058
27. Studies showthat CLDN1 is downregulated in lung adenocarcinoma and that low CLDN1 messenger ribonucleic acid (mRNA) expression leads to shorter overall survival. PMID: 27766775
28. The loss of claudin-1 appears to be involved in the pathogenesis of pterygium PMID: 26820697
29. autotypic tight junctions molecular composition, like claudin-1 and occludin expression could influence the demyelinating process by altering the permeability of the blood-nerve barrier. PMID: 26662145
30. High CLDN1 expression is associated with Cervical cancer. PMID: 26463354
31. Claudin-1 expression was correlated with lymphatic microvessel generation in hypopharyngeal squamous cell carcinoma and with patient survival. PMID: 26436506
32. High CLAUDIN-1 expression is associated with metastasis in follicular thyroid carcinoma. PMID: 26219679
33. The highest expression of claudin-1 was observed in well-differentiated oral squamous cell carcinomas, whereas poorly differentiated tumors exhibited mostly no expression of claudin-1. PMID: 25517868
34. Report genetic polymorphism of TJ component claudin-1 and their haplotypes are associated with leukoaraiosis. PMID: 25956626
35. Using a human liver-chimeric mouse model, we show that a monoclonal antibody specific for the TJ protein claudin-1 (ref. 7) eliminates chronic HCV infection without detectable toxicity PMID: 25798937
36. delocalization of claudin-1 induced by PKC phosphorylation contributes to metastatic capacity of osteosarcoma cells PMID: 26361141
37. The expressions of MARVELD2, CLDN1 and CLDN3 mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability. PMID: 25319490
38. There was no difference in the frequency of fractures or renal lithiasis between the rs219780 genotype groups in PHPT patients. Nor was there any relationship between the T or C alleles and BMD or biochemical parameters. PMID: 26554238
39. CLD1-mediated hepatoma cell invasiveness occurs via heat shock factor 1 (HSF1) activation. PMID: 26157141
40. Findings suggest that CLDN1 is oncogenic in gastric cancer and its malignant potential may be attributed in part to regulation of anoikis, by mediating membrane beta-catenin-regulated cell-cell adhesion and cell survival. PMID: 25544763
41. reduction of claudin-1 expression may contribute to the progression of gastric tumors PMID: 25755790
42. Data from live-cell imaging suggest at least two different cis-interaction interfaces within CLDN3 homopolymers as well as within CLDN1/CLDN3 heteropolymers. PMID: 25849148
43. Suggest that claudin 1 is an important messenger that regulates TNF-alpha-induced gene expression and migration in gastric cancer cells. PMID: 25548484
44. The findings suggest that down regulated CLDN1 and CLDN5 genes have potential relevance in relation to the progression of glioblastoma multiforme. PMID: 25345514
45. Positive expressions of Claudin-1 in retinoblastoma were fewer than those in retina; higher positive expressions were found in differentiated tissues than in undifferentiated tissues; Claudin-1 expressed more positively in optic nerves without invasion. PMID: 26122225
46. findings suggest that homozygous CD81 rs708564 TT may be a genetic modifier for avoiding HCV infection whether as a sole single nucleotide polymorphism or combined with the CLDN1 rs893051 GG genotype PMID: 25934191
47. Our results indicate that CLDN4 expression is correlated with poor prognosis, and CLDN1 expression may be an indicator of recurrence of oral squamous cell carcinoma. PMID: 25964581
48. CLDN1-negative phenotype predicts a high risk of recurrence and death in triple-negative breast cancer. PMID: 25393310
49. dystopic subcellular localizations of Snail-1 and claudin-1 may participate in changes of cellular morphology and behavior which might be associated with altered effectory pathways of proteins and thus substantially contribute to the cancer development. PMID: 22408413
50. Data show that C-terminal domain of Clostridium perfringens enterotoxin (cCPE)-binding to claudin 1 and claudin 5 is prevented by two residues in extracellular loop 2 of Cld1 (Asn(150) and Thr(153)) and Cld5 (Asp(149) and Thr(151)). PMID: 25342221

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HGNC: 2032

OMIM: 603718

KEGG: hsa:9076

STRING: 9606.ENSP00000295522

UniGene: Hs.439060