EDN1 Antibody

Datasheet
Code CSB-PA924161
Former Code(s) CSB-PA781368
Size US$299
Uniprot No. P05305
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA924161(EDN1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA924161(EDN1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
Immunogen Fusion protein of Human EDN1
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:2000-1:5000,IHC:1:50-1:200
Relevance The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias endothelin 1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names EDN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Endothelins are endothelium-derived vasoconstrictor peptides.
Involvement in disease Question mark ears, isolated (QME); Auriculocondylar syndrome 3 (ARCND3)
Subcellular Location Secreted
Protein Families Endothelin/sarafotoxin family
Tissue Specificity Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.
Database Links

HGNC: 3176

OMIM: 131240

KEGG: hsa:1906

STRING: 9606.ENSP00000368683

UniGene: Hs.511899

Pathway HIF-1 signaling pathway
Melanogenesis
TNF signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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