HK1 Antibody

Code CSB-PA002994
Size US$100
Order now
  • Western Blot analysis of HeLa cells using HXK I Polyclonal Antibody
  • Western Blot analysis of MOUSE-BRAIN cells using HXK I Polyclonal Antibody
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
Alternative Names
BB404130 antibody; Brain form hexokinase antibody; dea antibody; DrHXK1 antibody; EC antibody; Glycolytic enzyme antibody; HEXOKIN antibody; hexokinase I antibody; Hexokinase PI antibody; Hexokinase type I antibody; Hexokinase; tumor isozyme antibody; Hexokinase-1 antibody; Hexokinase-A antibody; HK I antibody; HK1 antibody; HK1 tb antibody; HK1 tc antibody; Hk1-s antibody; HK1-ta antibody; HK1-tb antibody; HK1-tc antibody; HKD antibody; HKI antibody; HMSNR antibody; HXK1 antibody; HXK1_HUMAN antibody; im:7148527 antibody; mHk1-s antibody; wu:fc09d08 antibody; wu:fc16e02 antibody; wu:fc21e02 antibody; wu:fq14b11 antibody; zgc:55790 antibody; zgc:77618 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the N-terminal region of Human HXK I.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome.
Gene References into Functions
  1. Mutation in c-Src phosphorylation site of either HK1 or HK2 remarkably abrogates the stimulating effects of c-Src on glycolysis, cell proliferation, migration, invasion, tumorigenesis and metastasis PMID: 28054552
  2. HK1 competes with SOD1 G93A mutant from familial amyotrophic lateral sclerosis cases for binding VDAC1. PMID: 27721436
  3. HK1 protein levels was decreased after luteolin treatment and partly restored when co-treated with luteolin and miR-34a inhibitor. PMID: 29054762
  4. The pathogenic nature of the identified missense mutations was confirmed by biochemical and 3-dimensional structural analysis. The effects of the novel splice site mutation c.873-2A>G were studied at the level of pre-mRNA processing, and confirmed at the protein level. Four of the 6 mutations studied were new. PMID: 27282571
  5. STAT3 expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC), while hexokinase II (HK-II) is predominantly upregulated and correlated to STAT3 in HBV-related HCC PMID: 26889748
  6. Russe type hereditary motor and sensory neuropathy belongs to the most frequent types of hereditary neuropathy in the Czech Republic, which affects Roma and is caused by a HK1 mutation. PMID: 26822750
  7. Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC). PMID: 26476538
  8. 4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG/Hexokinase 2 pathway PMID: 27012210
  9. Our results suggest that overexpression of PKM2 and HK1, especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer. PMID: 26464675
  10. The transport of glucose across the cell membrane by glucose transporters (GLUTs) and intracellular phosphorylation by hexokinases (HKs) are the initial steps of the glycolytic pathway. PMID: 25766729
  11. HK1 and HK2 expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples. PMID: 26855992
  12. Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members. PMID: 26427411
  13. HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex. PMID: 25904018
  14. HK-1 plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity. PMID: 25602755
  15. The present study was designed to evaluate the involvement of hexokinase and CPT-1 in the cell growth and proliferation of human prostate cancer cell lines, PC3, and LNCaP-FGC-10. PMID: 25501281
  16. HK1 is expressed in retina, with two abundant isoforms expressed at similar levels. The Glu847Lys mutation is located at a highly conserved position in the protein, outside the catalytic domains. PMID: 25190649
  17. Here, we identified HK1 as a novel causative gene for adRP. This is the first report that associates the glucose metabolic pathway with human retinal degenerative disease, suggesting a potential new disease mechanism. PMID: 25316723
  18. Hexokinase 1 (HK1) is a mitochondrial protein that controls the tramsmembrane potential and blocks apoptotic signals at the mitochondria. PMID: 24018046
  19. An increased ratio of HK1 protein in the extrasynaptic membrane/mitochondrial fraction of prefronal cortex was found in subjects with schizophrenia, suggesting that HK1 protein is abnormally partitioned in this illness PMID: 24560881
  20. A genetic association of myelomeningocele in Chile found polymorphisms for HK1. PMID: 23427181
  21. We detected mutation in the NDRG1 gene in two families and mutation in the HK1 gene in the other two families. These mutations cause Charcot-Marie-Tooth Disease, Type 4D and Charcot-Marie-Tooth disease, type 4g, respectively. PMID: 23996628
  22. Dominant, diazoxide-responsive HI in this family maps to a novel locus on Chr10q21-22. Disease-associated variants were found in non-coding regions of HK1 PMID: 23859901
  23. Data indicate that the most frequent form is SH3TC2 gene (CMT4C; 57.14%), followed by HK1 gene causative of CMT4G (CMT4G/HMSN-Russe 25%) and NDRG1 p.R148X in CMT type 4D (CMT4D/HMSN-Lom; 17.86%). PMID: 22978647
  24. The screening for novel Parkin substrate(s) identified mitochondrial hexokinase I (HKI) as a candidate. PMID: 23068103
  25. A key K8/K18 regulation of glucose metabolism in normal and cancerous hepatic cells through differential modulations of mitochondrial hexokinase status and insulin-mediated signaling. PMID: 23164509
  26. This study proposed that HK1 mitochondrial detachment could be linked to these disorders through impaired energy metabolism, increased vulnerability to oxidative stress, and impaired brain growth and development. PMID: 22018957
  27. An association is noted between the rs7072268 T-allele in HK1 and an increased blood glucose in non-diabetic individuals and a nominal association with type 2 diabetes prior to Bonferroni correction. PMID: 21781351
  28. Abeta-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in Alzheimer's disease PMID: 21179577
  29. FimA strengthens the VDAC1-hexokinase(I and II) interaction and prevents dissociation of hexokinase from VDAC1 triggered by apoptotic stimuli. PMID: 20347420
  30. The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported. PMID: 19536174
  31. REVIEW: Gene expression and biological significance of HK1 and HKR isoforms of hexokinase in erythroid cells. PMID: 12432216
  32. Glucose 6-phosphate binds to human brain hexokinase in mitochondria PMID: 16166083
  33. The role of the HK1 interdomain alpha-helix at the interdomain signal transduction was studied. PMID: 17080299
  34. Neither human hexokinase-1 nor human inorganic pyrophosphatase expression segregated concordantly with human cytoplasmic glutamic-oxaloacetic transaminase expression. PMID: 17494625
  35. single nucleotide polymorphisms on gene involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida PMID: 18212354
  36. interference with the binding of Hexokinase-I to mitochondria by VDAC1-derived peptides may offer a novel strategy by which to potentiate the efficacy of conventional chemotherapeutic agents PMID: 18308720
  37. results point to HK-I and HK-II as promoting tumor cell survival through binding to VDAC1, thereby inhibiting cytochrome c release and apoptotic cell death. PMID: 19049977
  38. Glycated hemoglobin levels are associated with genetic variation of HK1. PMID: 19096518
  39. The expression pattern of HK1 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry. PMID: 19554504
  40. reduced erythroid transcription of HK1 together with aberrant splicing of both hexokinase-1 and red cell specific-hexokinase results in hexokinase deficiency and mild chronic hemolysis. PMID: 19608687
  41. HK1 may influence A1C levels through its anemic effect or its effect on glucose metabolism in erythrocytes, which may have implications for type 2 diabetes diagnosis and care. PMID: 19651813
  42. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
  43. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380

Show More

Hide All

Involvement in disease
Hexokinase deficiency (HK deficiency); Neuropathy, hereditary motor and sensory, Russe type (HMSNR); Retinitis pigmentosa 79 (RP79)
Subcellular Location
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol.
Protein Families
Hexokinase family
Tissue Specificity
Isoform 2: Erythrocyte specific (Ref.6). Isoform 3: Testis-specific. Isoform 4: Testis-specific.
Database Links

HGNC: 4922

OMIM: 142600

KEGG: hsa:3098

STRING: 9606.ENSP00000384774

UniGene: Hs.370365

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join Us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2023 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details


II. Contact details


III. Ship To


IV. Bill To