LYPD3 Antibody, Biotin conjugated

Code CSB-PA013263LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) LYPD3 Polyclonal antibody
Uniprot No. O95274
Target Names LYPD3
Alternative Names 2310061G07Rik antibody; C4.4A antibody; GPI-anchored metastasis-associated protein C4.4A homolog antibody; GPI-anchored metastasis-associated protein homolog antibody; Ly6/PLAUR domain-containing protein 3 antibody; Lypd3 antibody; LYPD3_HUMAN antibody; Matrigel-induced gene C4 protein antibody; MIG-C4 antibody; SHINC3 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Ly6/PLAUR domain-containing protein 3 protein (31-326AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Gene References into Functions
  1. While in the healthy liver hepatocytes are C4.4A negative, data show that C4.4A is strongly expressed in hepatocellular carcinoma (HCC) with upregulation at the invasive front and in lung metastasis, indicating that C4.4A apparently contributes to HCC progression. PMID: 29048672
  2. Our results are consistent with previous data in mouse embryogenesis and wound healing. Based on these findings, we conclude that this human TES model provides an excellent surrogate for studies of C4.4A and Haldisin expressions in human stratified epithelia. PMID: 29075641
  3. Expression and crystallographic studies of the D1D2 domains of C4.4A have been reported. PMID: 28777093
  4. LYPD3 has a role in the maintenance of colorectal cancer stem-like cells. PMID: 28238780
  5. Highly expressed C4.4A protein in HER2-positive human breast cancers indicate a good prognosis. PMID: 23918676
  6. overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome. PMID: 24935570
  7. expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions PMID: 25414274
  8. Tenascin-C expression was significantly associated with C4.4A expression in clinical esophageal squamous carcinoma samples suggesting that there may be a functional role for the C4.4A to induceTenascin-C in vivo. PMID: 23708783
  9. findings suggest that a tight association between C4.4A and tumor budding may, in part, be due to C4.4A promoting epithelial-mesenchymal transition at the invasive front of colorectal cancer PMID: 22404718
  10. the first explanation for the C4.4A contribution to wound healing and metastasis. PMID: 22431918
  11. data indicate that expression of the C4.4A protein at the invasive front acts as a novel prognostic marker in colorectal cancer, possibly through invasion-related mechanisms PMID: 20825414
  12. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan PMID: 12592373
  13. High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients. PMID: 17706320
  14. Overexpression of C4.4A is associated with invasion and metastasis of esophageal squamous cell carcinoma PMID: 17849475
  15. we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids PMID: 17912244
  16. cleavage of C4.4A by ADAM10 and ADAM17 contributes to tumor progression PMID: 18979631

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Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TC
Database Links

HGNC: 24880

OMIM: 609484

KEGG: hsa:27076

STRING: 9606.ENSP00000244333

UniGene: Hs.631594

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