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| Code | CSB-PA598712 |
| Product Type | Polyclonal Antibody |
| Former Code(s) | CSB-PA928317 |
| Size | US$297 |
| Uniprot No. | P01106 |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Peptide sequence around aa.56~60 (L-P-T-P-P) derived from Human Myc. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Specificity | The antibody detects endogenous level of total Myc protein. |
| Tested Applications | ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200 |
| Relevance | Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The expression correlates with the proliferation state of the cells. Transcription is repressed in quiescent or terminally differentiated cells. Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. Myc therefore is an important positive regulator of cell growth and proliferation. Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. Apoptosis may serve also as a protective mechanism to prevent tumorigenicity elicited by deregulated Myc expression. Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates Jin Z, et al. (2004) J Biol Chem. 279(38): 40209-40219. Welcker M, et al. (2004) Proc Natl Acad Sci U S A. 101(24): 9085-9090. Baudino T A, et al. (2001) Mol Cell Biol. 21: 691-702. Blackwood E M, et al. (1991) Science. 251:1211-1217. Henriksson M, et al. (1996) Adv Cancer Res. 68: 109-182. |
| Form | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Clonality | Polyclonal |
| Alias | c-myc |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | MYC |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis |
| Involvement in disease | Burkitt lymphoma (BL) |
| Subcellular Location | Nucleus, nucleoplasm, Nucleus, nucleolus |
| Database Links |
HGNC: 7553 OMIM: 113970 KEGG: hsa:4609 STRING: 9606.ENSP00000367207 UniGene: Hs.202453 |
| Pathway |
ErbB signaling pathway
Hippo signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway TGF-beta signaling pathway Wnt signaling pathway Cell cycle Cellular senescence Signaling pathways regulating pluripotency of stem cells |
MYC Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA015270GA01HU | MYC Antibody | Human,Mouse,Rat | ELISA,WB, IP, IHC, IF, FC |
| CSB-RA015270A62phHU | Phospho-MYC (S62) Antibody | Human | ELISA, WB, IF |
| CSB-RA015270A58-62phHU | Phospho-MYC (T58+S62) Antibody | Human | ELISA, WB |
| CSB-PA930453 | MYC (Ab-358) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA945395 | Phospho-MYC (Thr58) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA239396 | Phospho-MYC (Thr358) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA038920 | Phospho-MYC (Ser373) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA062361 | Phospho-MYC (Ser62) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA552586 | MYC (Ab-373) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA153029 | MYC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000389 | MYC Antibody | Human | WB |
| CSB-PA000503 | Phospho-MYC (T58) Antibody | Human,Mouse,Rat | WB,IHC,IP,ELISA |
| CSB-PA000729 | Phospho-MYC (S62) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA001729 | MYC Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA010301 | Phospho-MYC (S373) Antibody | Human,Mouse,Rat | IHC,IP,ELISA |
| CSB-PA010303 | Phospho-MYC (T358) Antibody | Human,Mouse,Rat | IHC,IP,ELISA |
| CSB-PA407491 | MYC Antibody | Human,Rat | ELISA,WB,IHC |
MYC Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA02589A0Rb | MYC Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA02589B0Rb | MYC Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02589C0Rb | MYC Antibody, FITC conjugated | Human | ELISA |
| CSB-PA02589D0Rb | MYC Antibody, Biotin conjugated | Human | ELISA |
MYC Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP015270HU CSB-BP015270HU CSB-MP015270HU |
Recombinant Human Myc proto-oncogene protein(MYC) | Yeast Baculovirus Mammalian cell |
| CSB-EP015270HU | Recombinant Human Myc proto-oncogene protein(MYC),Escherichia Coli | E.coli |
| CSB-RP025844h | Recombinant Human Myc proto-oncogene protein(MYC) | E.coli |
| CSB-EP015270HU1 | Recombinant Human Myc proto-oncogene protein(MYC),partial | E.coli |
MYC ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E09260h | Human c-myc Oncogene product,c-myc ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
2-hydroxyisobutyryl-HIST1H2BC (K24) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
