NGF Antibody, HRP conjugated

Datasheet
Code CSB-PA643662LB01HU
Size US$299
Uniprot No. P01138
Protocols ELISA Protocol
Immunogen Recombinant Human Beta-nerve growth factor protein (122-218AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Beta-nerve growth factor (Beta-NGF), NGF, NGFB
Immunogen Species Human
Research Area Neuroscience
Target Names NGF
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI
Involvement in disease Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)
Subcellular Location Secreted
Protein Families NGF-beta family
Database Links

HGNC: 7808

OMIM: 162030

KEGG: hsa:4803

STRING: 9606.ENSP00000358525

UniGene: Hs.2561

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Ras signaling pathway
Rap1 signaling pathway
Inflammatory Pain
Inhibitors of axonal regeneration

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