NGF Research Reagents

Beta-nerve growth factor is a protein in humans that is encoded by NGF gene. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.

The following NGF reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NGF Antibodies

NGF Antibodies for Rattus norvegicus (Rat)

NGF Antibodies for Homo sapiens (Human)

NGF Antibodies for Sus scrofa (Pig)

NGF Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

NGF Proteins

NGF Proteins for Bos taurus (Bovine)

NGF Proteins for Cavia porcellus (Guinea pig)

NGF Proteins for Rattus norvegicus (Rat)

NGF Proteins for Homo sapiens (Human)

NGF Proteins for Gallus gallus (Chicken)

NGF Proteins for Mus musculus (Mouse)

NGF Proteins for Mastomys natalensis (African soft-furred rat) (Praomys natalensis)

NGF Proteins for Xenopus laevis (African clawed frog)

NGF Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

NGF Proteins for Sus scrofa (Pig)

NGF Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

NGF Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NGF Proteins for Bothrops jararacussu (Jararacussu)

NGF Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

NGF Proteins for Pongo pygmaeus (Bornean orangutan)

NGF Proteins for Pan troglodytes (Chimpanzee)

NGF ELISA Kit

NGF ELISA Kit for Homo sapiens (Human)

NGF ELISA Kit for Mus musculus (Mouse)

NGF ELISA Kit for Rattus norvegicus (Rat)

NGF Background

The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ). As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence [1]. The NGFβ protein functions by binding to its receptors, which initiates signaling pathways inside the cell. The NGFβ protein can bind to two different receptors, the NTRK1 receptor or the p75NTR receptor. Both receptors are found on the surface of sensory neurons and other types of neurons. The binding of the NGFβ protein to the NTRK1 receptor signals these neurons to grow and to mature and take on specialized functions (differentiate). This binding also blocks signals that initiate the process of self-destruction (apoptosis). Additionally, NGFβ signaling through NTRK1 plays a role in pain sensation. It is less clear what binding with the p75NTR receptor signals. Studies suggest that p75NTR signaling can help sensory neurons grow and differentiate but can also trigger apoptosis. However, several recent studies suggest that NGF is also involved in pathways regulating the life cycle of neurons.

[1] Freeman RS, Burch RL, et al. NGF deprivation-induced gene expression: after ten years, where do we stand [J]? Progress in Brain Research. 2004, 146: 111–26.

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