NGF, also known as Nerve Growth Factor, is a protein that is widely present in various tissues, particularly playing a significant role in the central and peripheral nervous systems. NGF is encoded by its own gene in human cells and was initially isolated and purified from mouse tumors, snake venom, and male mouse salivary glands. The mechanism of action for NGF primarily involves binding to its high-affinity receptor TrkA, activating tyrosine kinase activity within cells, and triggering downstream signaling pathways such as PI3K-Akt and MAPK, promoting neuronal survival, differentiation, and growth. Additionally, NGF can bind to the low-affinity receptor p75NTR, participating in the regulation of cell apoptosis and other processes.
Biologically, NGF is crucial for the development and maturation of the nervous system, especially in promoting the survival and functional expression of specific types of neurons. NGF's activity is also related to the regulation of immune cell activity, inhibition of mitosis in tumor cells, and wound healing processes. In terms of disease treatment, NGF is being studied for use in treating a variety of conditions, including Alzheimer’s disease, Parkinson’s disease, diabetic neuropathy, and acute neurological injuries.
Recombinant Human Beta-nerve growth factor (NGF) (CSB-EP015779HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NGF Recombinant Monoclonal Antibody (CSB-RA015779MA1HU)
Validated Data
Overlay Peak curve showing PC3 cells stained with CSB-RA015779MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following NGF reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NGF Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA16859B0Rb | Ngf Antibody, HRP conjugated | Rat | ELISA |
CSB-PA16859A0Rb | Ngf Antibody | Rat | ELISA, IP |
NGF Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015779GA01HU | NGF Antibody | Human | ELISA,IHC |
CSB-PA003446 | NGF Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA006132 | NGF Antibody | Human | WB, ELISA |
CSB-PA942456 | NGF Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA558560 | NGF Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA643662LA01HU | NGF Antibody | Human | ELISA, IHC |
CSB-PA643662LB01HU | NGF Antibody, HRP conjugated | Human | ELISA |
CSB-PA643662LC01HU | NGF Antibody, FITC conjugated | Human | |
CSB-PA643662LD01HU | NGF Antibody, Biotin conjugated | Human | ELISA |
CSB-RA288635A0HU | NGF Recombinant Monoclonal Antibody | Human, Rat | ELISA, WB, IHC |
CSB-RA015779MA1HU | NGF Recombinant Monoclonal Antibody | Human | ELISA, FC |
NGF Antibodies for Sus scrofa (Pig)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA643662LA01PI | NGF Antibody | Pig | ELISA |
CSB-PA643662LB01PI | NGF Antibody, HRP conjugated | Pig | ELISA |
CSB-PA643662LC01PI | NGF Antibody, FITC conjugated | Pig | |
CSB-PA643662LD01PI | NGF Antibody, Biotin conjugated | Pig | ELISA |
NGF Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA751089XA01DIL | ngf Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
NGF Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP015779BO CSB-EP015779BO CSB-BP015779BO CSB-MP015779BO CSB-EP015779BO-B |
Recombinant Bovine Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP015779GU CSB-EP015779GU CSB-BP015779GU CSB-MP015779GU CSB-EP015779GU-B |
Recombinant Guinea pig Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP015779RA | Recombinant Rat Beta-nerve growth factor (Ngf) | Yeast |
CSB-EP015779RA CSB-BP015779RA CSB-MP015779RA CSB-EP015779RA-B |
Recombinant Rat Beta-nerve growth factor (Ngf) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP015779RA1 | Recombinant Rat Beta-nerve growth factor (Ngf), partial | E.coli |
NGF Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015779HU CSB-BP015779HU CSB-MP015779HU CSB-EP015779HU-B |
Recombinant Human Beta-nerve growth factor (NGF) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP003771HU | Recombinant Human Beta-nerve growth factor (NGF) (Active) | E.coli |
CSB-AP003951HU | Recombinant Human Beta-nerve growth factor (NGF), partial (Active) | Mammalian cell |
CSB-EP015779HU | Recombinant Human Beta-nerve growth factor (NGF) | E.coli |
NGF Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015779CH CSB-EP015779CH CSB-BP015779CH CSB-MP015779CH CSB-EP015779CH-B |
Recombinant Chicken Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015779MO CSB-EP015779MO CSB-BP015779MO CSB-MP015779MO CSB-EP015779MO-B |
Recombinant Mouse Beta-nerve growth factor (Ngf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP004081MO | Recombinant Mouse Beta-nerve growth factor (Ngf), partial (Active) | E.coli |
CSB-AP004101MO | Recombinant Mouse Beta-nerve growth factor (Ngf) (Active) | E.coli |
NGF Proteins for Mastomys natalensis (African soft-furred rat) (Praomys natalensis)
Code | Product Name | Source |
---|---|---|
CSB-YP015779PRP CSB-EP015779PRP CSB-BP015779PRP CSB-MP015779PRP CSB-EP015779PRP-B |
Recombinant Praomys natalensis Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP324224XBE CSB-EP324224XBE CSB-BP324224XBE CSB-MP324224XBE CSB-EP324224XBE-B |
Recombinant Xenopus laevis Nerve growth factor (ngf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Code | Product Name | Source |
---|---|---|
CSB-YP341491XAS CSB-EP341491XAS CSB-BP341491XAS CSB-MP341491XAS CSB-EP341491XAS-B |
Recombinant Xiphophorus maculatus Nerve growth factor (ngf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP643662PI CSB-BP643662PI CSB-MP643662PI CSB-EP643662PI-B |
Recombinant Pig Beta-nerve growth factor (NGF) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP643662PI | Recombinant Pig Beta-nerve growth factor (NGF) | E.coli |
NGF Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP705448SWC CSB-EP705448SWC CSB-BP705448SWC CSB-MP705448SWC CSB-EP705448SWC-B |
Recombinant Saimiri boliviensis boliviensis Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP751089DIL CSB-EP751089DIL CSB-BP751089DIL CSB-MP751089DIL CSB-EP751089DIL-B |
Recombinant Danio rerio Nerve growth factor (ngf) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Bothrops jararacussu (Jararacussu)
Code | Product Name | Source |
---|---|---|
CSB-YP852675BUX CSB-EP852675BUX CSB-BP852675BUX CSB-MP852675BUX CSB-EP852675BUX-B |
Recombinant Bothrops jararacussu Venom nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-YP868235GGZ CSB-EP868235GGZ CSB-BP868235GGZ CSB-MP868235GGZ CSB-EP868235GGZ-B |
Recombinant Gorilla gorilla gorilla Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Pongo pygmaeus (Bornean orangutan)
Code | Product Name | Source |
---|---|---|
CSB-YP873567EXP CSB-EP873567EXP CSB-BP873567EXP CSB-MP873567EXP CSB-EP873567EXP-B |
Recombinant Pongo pygmaeus Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP882018EQV CSB-EP882018EQV CSB-BP882018EQV CSB-MP882018EQV CSB-EP882018EQV-B |
Recombinant Pan troglodytes Beta-nerve growth factor (NGF) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NGF ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04683h | Human Nerve growth factor,NGF ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates. | 6.86 pg/ml. |
NGF ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04684m | Mouse Nerve growth factor,NGF ELISA kit | serum, plasma, tissue homogenates. | 15.6 pg/ml |
NGF ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04685r | Rat Nerve growth factor,NGF ELISA kit | serum, plasma, tissue homogenates | 0.195 pg/mL |