PRKAA1 Antibody

^Datasheet

Specification
Target

Code	CSB-PA071831
Size	US$299
Uniprot No.	Q13131
Image	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA071831(PRKAA1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA071831(PRKAA1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: CSB-PA071831(PRKAA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Immunogen	Synthetic peptide of Human PRKAA1
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Tested Applications	ELISA,WB,IHC;ELISA:1:2000-1:10000,WB:1:200-1:1000,IHC:1:100-1:300
Relevance	The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method	Antigen affinity purification
Isotype	IgG
Alias	protein kinase, AMP-activated, alpha 1 catalytic subunit
Immunogen Species	Homo sapiens (Human)
Protocols	ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol
Target Names	PRKAA1
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes
Subcellular Location	Cytoplasm, Nucleus
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Database Links	HGNC: 9376 OMIM: 602739 KEGG: hsa:5562 STRING: 9606.ENSP00000346148 UniGene: Hs.43322
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling Apelin signaling pathway FoxO signaling pathway Glucagon signaling pathway Insulin signaling pathway

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PRKAA1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA618759KA01HU	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IP
CSB-PA261465	Phospho-PRKAA1/PRKAA2 (Ser487) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA592613	PRKAA1/PRKAA2 (Ab-487) Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA913725	PRKAA1 (Ab-174/172) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA131259	PRKAA1 Antibody	Human,Mouse,Rat	WB,IHC,IF,ELISA
CSB-PA953053	Phospho-PRKAA1 (S496) Antibody	Human,Mouse,Rat	WB,IHC,ELISA
CSB-PA865713	PRKAA1 Antibody	Human,Mouse,Rat	WB
CSB-PA801858	PRKAA1 Antibody	Human,Mouse,Rat	WB,IHC
CSB-PA228254	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA345903	PRKAA1 Antibody	Human,Mouse,Rat	ELISA,IHC

PRKAA1 Antibodies for Human

Code	Product Name	Species Reactivity	Application
CSB-PA618759LA01HU	PRKAA1 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA618759LB01HU	PRKAA1 Antibody, HRP conjugated	Human	ELISA
CSB-PA618759LC01HU	PRKAA1 Antibody, FITC conjugated	Human	ELISA
CSB-PA618759LD01HU	PRKAA1 Antibody, Biotin conjugated	Human	ELISA

PRKAA1 Proteins

PRKAA1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP618759HU CSB-EP618759HU CSB-BP618759HU CSB-MP618759HU	Recombinant Human 5'-AMP-activated protein kinase catalytic subunit alpha-1(PRKAA1)	Yeast E.coli Baculovirus Mammalian cell

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