PRKACG Antibody

Datasheet

Code	CSB-PA030216
Size	US$119
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Image	Western Blot analysis of COLO205 cells using PKAγ cat Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P22612

Target Names

PRKACG

Alternative Names

cAMP-dependent protein kinase catalytic subunit gamma antibody; KAPCG_HUMAN antibody; KAPG antibody; PKA C gamma antibody; PKA C-gamma antibody; PKACg antibody; PRKACG antibody; Protein kinase cAMP dependent catalytic gamma antibody; Serine (threonine) protein kinase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the N-terminal region of Human PKAγ cat.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Gene References into Functions

The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A in megakaryocytes. PMID: 25061177
PKA-mediated phosphorylation of GPIbbeta at Ser(166) negatively regulates VWF binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition PMID: 12361948
Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation. PMID: 15039079

Involvement in disease

Bleeding disorder, platelet-type 19 (BDPLT19)

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily

Tissue Specificity

Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.

Database Links

HGNC: 9382

OMIM: 176893

KEGG: hsa:5568

STRING: 9606.ENSP00000366488

UniGene: Hs.158029

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Calcium signaling pathway cAMP signaling pathway Chemokine signaling pathway Estrogen signaling pathway Hedgehog signaling pathway MAPK signaling pathway Melanogenesis Wnt signaling pathway Gap junction Vascular smooth muscle contraction Autophagy Ras signaling pathway Th17 cell differentiation Apelin signaling pathway Glucagon signaling pathway Insulin signaling pathway Glutamatergic synapse G protein coupled receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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