Phospho-EIF2AK4 (T899) Antibody

Datasheet
Code CSB-PA010224
Size US$167
Uniprot No. Q9P2K8
Immunogen Synthesized peptide derived from Human GCN2 around the phosphorylation site of T899.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications IHC,ELISA;IHC:1/100-1/300.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias EIF2AK4; GCN2; KIAA1338; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein
Immunogen Species Homo sapiens (Human)
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names EIF2AK4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability
Involvement in disease Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2)
Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
Database Links

HGNC: 19687

OMIM: 234810

KEGG: hsa:440275

STRING: 9606.ENSP00000263791

UniGene: Hs.656673

Pathway Autophagy
Protein processing in endoplasmic reticulum

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