Phospho-PTPRC (S1007) Antibody

Datasheet
Code CSB-PA040112
Size US$167
Uniprot No. P08575
Protocols Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human CD45 around the phosphorylation site of S1007.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IF,ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
Immunogen Species Homo sapiens (Human)
Target Names PTPRC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis (MS)
Subcellular Location Membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Database Links

HGNC: 9666

OMIM: 126200

KEGG: hsa:5788

STRING: 9606.ENSP00000356346

UniGene: Hs.654514

Pathway Fc gamma R-mediated phagocytosis
T cell receptor signaling pathway

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