RAB10 Antibody

Code CSB-PA019152LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA019152LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA019152LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA019152LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) RAB10 Polyclonal antibody
Uniprot No. P61026
Target Names RAB10
Alternative Names GTP binding protein RAB10 antibody; Rab10 antibody; RAB10 member RAS oncogene family antibody; RAB10_HUMAN antibody; Ras related GTP binding protein antibody; Ras related GTP binding protein RAB10 antibody; Ras-related protein Rab-10 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Ras-related protein Rab-10 protein (1-196AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed
Gene References into Functions
  1. miR378a3p may act as a tumorsuppressor in Esophageal squamous cell carcinoma cells through negatively regulating Rab10. PMID: 29693138
  2. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils has been reported. PMID: 29127255
  3. Our results suggest that RAB10 could be a promising therapeutic target for Alzheimer's Disease prevention PMID: 29183403
  4. RAB10 regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways. More importantly, high RAB10 expression levels in HCC cells correlated with a poor prognosis in HCC patients. PMID: 28460436
  5. miR-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR-329 in osteosarcoma and mediates its biofunction PMID: 27487475
  6. Data suggest that MGCRABGAP is involved in mammalian spermiogenesis by modulating RAB10. PMID: 28067790
  7. the target gene RAB10 regulated by miRNA-369-3p, miRNA-30e-5p, miRNA-30e-3p, and miRNA-655 may play key role in the progression and development of AD. PMID: 26082458
  8. The Anaplasma phagocytophilum surface protein, uridine monophosphate kinase, was identified as a guanine nucleotide-independent, Rab10-specific ligand. PMID: 26289115
  9. Rab10 is a target of the GTPase-activating protein AS160, which is inhibited after phosphorylation by the protein kinase Akt. PMID: 25103239
  10. Rab10 silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed hyaluronan synthesis. PMID: 24509846
  11. Rab10 regulates endoplasmic reticulum dynamics/morphology. Suggest that these dynamics could be coupled to phospholipid synthesis. PMID: 23263280
  12. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C PMID: 21454697
  13. Rab10 and Rab8A are new cytoplasmic factors implicated in WPB biogenesis that play a role in generating granules that can rapidly respond to secretagogue PMID: 21070595
  14. Rab10, acting upstream of Rab5, plays a prominent role in phagolysosome formation and can modulate Mycobacterium-containing phagosomes maturation PMID: 20028485
  15. Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis. PMID: 15855153
  16. a related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc PMID: 19008234

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Subcellular Location Cytoplasmic vesicle membrane, Lipid-anchor, Cytoplasmic side, Golgi apparatus membrane, Golgi apparatus, trans-Golgi network membrane, Endosome membrane, Recycling endosome membrane, Cytoplasmic vesicle, phagosome membrane, Cell projection, cilium, Endoplasmic reticulum membrane
Protein Families Small GTPase superfamily, Rab family
Database Links

HGNC: 9759

OMIM: 612672

KEGG: hsa:10890

STRING: 9606.ENSP00000264710

UniGene: Hs.467960

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