Your Good Partner in Biology Research
Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-PA019152LA01HU |
| See More Details |  |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Human RAB10 Polyclonal antibody | ||||||
| Uniprot No. | P61026 | ||||||
| Target Names | RAB10 | ||||||
| Alternative Names | Ras-related protein Rab-10, RAB10 | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human | ||||||
| Immunogen | Recombinant Human Ras-related protein Rab-10 protein (1-196AA) | ||||||
| Immunogen Species | Human | ||||||
| Conjugate | Non-conjugated | ||||||
| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Purification Method | >95%, Protein G purified | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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| Form | Liquid | ||||||
| Tested Applications | ELISA, IHC, IF | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. | ||||||
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed |
| Subcellular Location | Cytoplasmic vesicle membrane, Lipid-anchor, Cytoplasmic side, Golgi apparatus membrane, Golgi apparatus, trans-Golgi network membrane, Endosome membrane, Recycling endosome membrane, Cytoplasmic vesicle, phagosome membrane, Cell projection, cilium, Endoplasmic reticulum membrane |
| Protein Families | Small GTPase superfamily, Rab family |
| Database Links |
HGNC: 9759 OMIM: 612672 KEGG: hsa:10890 STRING: 9606.ENSP00000264710 UniGene: Hs.467960 |
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