TGFBR2 Antibody

Datasheet
Code CSB-PA782688
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P37173
Image
  • Western blot analysis of extracts from HepG2 cells, using TGF β Receptor II antibody.
Immunogen Synthesized peptide derived from Human TGF β Receptor II antibody.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous levels of total TGF β Receptor II protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Herbert Y. Lin, J. Biol. Chem., Feb 1995; 270: 2747.
Michitomo Sakuma, Int. Immunol., Feb 2007; 19: 117 - 126.
Elisabetta del Re, J. Biol. Chem., May 2004; 279: 22765 - 22772.
M Laiho, J. Biol. Chem., Oct 1990; 265: 18518 - 18524.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias GF-beta type II receptor; TGF-betaR2; TGFR-2; TGFR2; kinase TGF-beta-R2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names TGFBR2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Involvement in disease Hereditary non-polyposis colorectal cancer 6 (HNPCC6); Esophageal cancer (ESCR); Loeys-Dietz syndrome 2 (LDS2)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Database Links

HGNC: 11773

OMIM: 133239

KEGG: hsa:7048

STRING: 9606.ENSP00000351905

UniGene: Hs.604277

Pathway Hippo signaling pathway
MAPK signaling pathway
TGF-beta signaling pathway
Adherens junction
Cellular senescence
Osteoclast differentiation
Th17 cell differentiation
AGE-RAGE signaling pathway in diabetic complications
FoxO signaling pathway
Endocytosis

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