TGFBR2, also known as Transforming Growth Factor Beta Receptor 2 or TGFβR-II, is a transmembrane protein encoded by the TGFBR2 gene and primarily functions on the cell surface. Its mechanism of action includes binding to the Transforming Growth Factor Beta (TGF-β) family of ligands, which activates its intrinsic serine/threonine kinase activity. This activation leads to the phosphorylation and subsequent activation of Smad proteins. The activated Smads then translocate to the nucleus to regulate the expression of target genes. TGFBR2 plays a pivotal role in processes such as cell proliferation, differentiation, migration, and apoptosis, influencing biological processes like tissue development, immune regulation, fibrosis, and tumorigenesis.
Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial (CSB-EP023452HU1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TGFBR2 Antibody (CSB-PA023452LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA023452LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA023452LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA023452LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following TGFBR2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TGFBR2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA120767 | TGFBR2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA911102 | Phospho-TGFBR2 (Ser225/250) Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA782688 | TGFBR2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA004277 | TGFBR2 Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA004278 | TGFBR2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050249 | Phospho-TGFBR2 (S225) Antibody | Human,Mouse | IHC, ELISA |
CSB-PA023452LA01HU | TGFBR2 Antibody | Human | ELISA, IHC, IF |
CSB-PA023452LB01HU | TGFBR2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA023452LC01HU | TGFBR2 Antibody, FITC conjugated | Human | |
CSB-PA023452LD01HU | TGFBR2 Antibody, Biotin conjugated | Human | ELISA |
TGFBR2 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023452ZA01RA | Tgfbr2 Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
TGFBR2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP023452RA1 CSB-MP023452RA1 CSB-EP023452RA1-B |
Recombinant Rat TGF-beta receptor type-2 (Tgfbr2), partial | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF023452RA | Recombinant Rat TGF-beta receptor type-2 (Tgfbr2) | in vitro E.coli expression system |
CSB-BP023452RA1 | Recombinant Rat TGF-beta receptor type-2 (Tgfbr2), partial | Baculovirus |
CSB-EP023452RA1 | Recombinant Rat TGF-beta receptor type-2 (Tgfbr2), partial | E.coli |
TGFBR2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP023452HU1 CSB-BP023452HU1 CSB-MP023452HU1 CSB-EP023452HU1-B |
Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF023452HU | Recombinant Human TGF-beta receptor type-2 (TGFBR2) | in vitro E.coli expression system |
CSB-EP023452HU1 | Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial | E.coli |
CSB-MP023452HU2 | Recombinant Human TGF-beta receptor type-2 (TGFBR2), partial | Mammalian cell |
TGFBR2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP720297MO CSB-EP720297MO CSB-BP720297MO CSB-MP720297MO CSB-EP720297MO-B |
Recombinant Mouse TGF-beta receptor type-2 (Tgfbr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TGFBR2 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP849542CH CSB-EP849542CH CSB-BP849542CH CSB-MP849542CH CSB-EP849542CH-B |
Recombinant Chicken TGF-beta receptor type-2 (TGFBR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TGFBR2 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-CF023452PI | Recombinant Pig TGF-beta receptor type-2 (TGFBR2) | in vitro E.coli expression system |
CSB-YP023452PI1 CSB-EP023452PI1 CSB-BP023452PI1 CSB-MP023452PI1 CSB-EP023452PI1-B |
Recombinant Pig TGF-beta receptor type-2 (TGFBR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TGFBR2 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13669h | Human transforming growth factor β receptor 2 (TGF-βR2) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |