TLR4 Antibody

Code CSB-PA023603GA01HU
Product Type Purified Rabbit Anti Homo sapiens PolyClonal Antibody
Size US$685
Uniprot No. O00206
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human TLR4
Raised in Rabbit
Species Reactivity Human,Mouse,Rat,Bovin
Tested Applications ELISA,WB
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias toll-like receptor 4;TLR4;ARMD10;CD284;TOLL;hToll ;
Immunogen Species Homo sapiens (Human)
Target Names TLR4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
HGNC 28631
RGD 1307636
MGI 1913705
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Function Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Early endosome
Protein Families Toll-like receptor family
Tissue Specificity Highly expressed in placenta, spleen and peripheral blood leukocytes (PubMed:9435236, PubMed:9237759). Detected in monocytes, macrophages, dendritic cells and several types of T-cells (PubMed:9237759, PubMed:27022195).
Database Links

HGNC: 11850

OMIM: 603030

KEGG: hsa:7099

STRING: 9606.ENSP00000363089

UniGene: Hs.174312

Pathway HIF-1 signaling pathway
PI3K-Akt signaling pathway
Lipids and Inflammation in Atherogenesis
NF-kappa B signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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