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| Code | CSB-PA024148LB01HU |
| Size | US$299 |
| Uniprot No. | Q13114 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human TNF receptor-associated factor 3 protein (1-40AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. |
| Form | Liquid |
| Conjugate | HRP |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3), TRAF3, CAP1 CRAF1 |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Immunology |
| Target Names | TRAF3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. |
| Involvement in disease | Herpes simplex encephalitis 3 (HSE3) |
| Subcellular Location | Cytoplasm, Endosome, Mitochondrion |
| Protein Families | TNF receptor-associated factor family, A subfamily |
| Database Links |
HGNC: 12033 OMIM: 601896 KEGG: hsa:7187 STRING: 9606.ENSP00000376500 UniGene: Hs.510528 |
| Pathway |
NF-kappa B signaling pathway
TNF signaling pathway IL-17 signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway |
TRAF3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA024148GA01HU | TRAF3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA024148LC01HU | TRAF3 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004324 | TRAF3 Antibody | Human,Mouse | WB,ELISA |
| CSB-PA594760 | TRAF3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA940722 | TRAF3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA024148LD01HU | TRAF3 Antibody, Biotin conjugated | Human | ELISA |
TRAF3 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA024148LA01HU | TRAF3 Antibody | Human | ELISA, WB, IF |
TRAF3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP024148HU | Recombinant Human TNF receptor-associated factor 3(TRAF3) | E.coli |
| CSB-YP024148HU CSB-BP024148HU CSB-MP024148HU |
Recombinant Human TNF receptor-associated factor 3(TRAF3) | Yeast Baculovirus Mammalian cell |
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