TRAF3 Antibody, HRP conjugated

Datasheet
Code CSB-PA024148LB01HU
Size US$299
Uniprot No. Q13114
Immunogen Recombinant Human TNF receptor-associated factor 3 protein (1-40AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3), TRAF3, CAP1 CRAF1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Immunology
Target Names TRAF3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Involvement in disease Herpes simplex encephalitis 3 (HSE3)
Subcellular Location Cytoplasm, Endosome, Mitochondrion
Protein Families TNF receptor-associated factor family, A subfamily
Database Links

HGNC: 12033

OMIM: 601896

KEGG: hsa:7187

STRING: 9606.ENSP00000376500

UniGene: Hs.510528

Pathway NF-kappa B signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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