TRAF3 Antibody

Datasheet
Code CSB-PA004324
Size US$167
Uniprot No. Q13114
Image
  • Western Blot analysis of COLO205 cells using TRAF3 Polyclonal Antibody
  • Western Blot analysis of Jurkat K562 cells using TRAF3 Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the Internal region of Human TRAF3.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications WB,ELISA;WB:1/500-1/2000.IHC:1/200-1/1000.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias TRAF3; CAP1; CRAF1; TNF receptor-associated factor 3; CAP-1; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein 1; LAP1
Immunogen Species Homo sapiens (Human)
Target Names TRAF3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Involvement in disease Herpes simplex encephalitis 3 (HSE3)
Subcellular Location Cytoplasm, Endosome, Mitochondrion
Protein Families TNF receptor-associated factor family, A subfamily
Database Links

HGNC: 12033

OMIM: 601896

KEGG: hsa:7187

STRING: 9606.ENSP00000376500

UniGene: Hs.510528

Pathway NF-kappa B signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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