TRAF3 Antibody

Datasheet
Code CSB-PA940722
Size US$299
Uniprot No. Q13114
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA940722(TRAF3 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8+10+12%SDS-PAGE, Lysate: 60 μg, Lane: Mouse kidney tissue, Primary antibody: CSB-PA940722(TRAF3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human TRAF3
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:200-1:1000,IHC:1:25-1:100
Relevance The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias TNF receptor-associated factor 3
Immunogen Species Homo sapiens (Human)
Target Names TRAF3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Involvement in disease Herpes simplex encephalitis 3 (HSE3)
Subcellular Location Cytoplasm, Endosome, Mitochondrion
Protein Families TNF receptor-associated factor family, A subfamily
Database Links

HGNC: 12033

OMIM: 601896

KEGG: hsa:7187

STRING: 9606.ENSP00000376500

UniGene: Hs.510528

Pathway NF-kappa B signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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