Recombinant Human Bone morphogenetic protein 4 (BMP4)

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Code CSB-EP002740HU
Size $224
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Greater than 90% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Developmental Biology
Alternative Names
zgc:100779; BMP 2B; BMP 4; BMP-2B; BMP-4; BMP2B; BMP2B1; BMP4; BMP4_HUMAN; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; DVR4; MCOPS6; MGC100779; OFC11; zbmp-4; ZYME
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-SUMO-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

The gene coding for the Human BMP4 protein (293-408aa) is introduced into a plasmid vector, creating recombinant plasmid that is subsequently transformed into e.coli cells. e.coli cells capable of surviving in the presence of a specific antibiotic are selected and then cultured under conditions favorable for the expression of the gene of interest. A N-terminal 6xHis-SUMO tag is attached to the protein. Post-expression, the recombinant Human BMP4 protein is isolated and purified from the cell lysate using affinity purification. Denaturing SDS-PAGE is applied to resolve the resulting recombinant Human BMP4 protein, revealing a purity exceeding 90%.

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Could you send a price to me for the following below. These will be used on the Biocore so if you can recommend a good purity version, that would be great.
500ug of Human BMP4

Thanks for your inquiry. I checked with our protein center and recommend these products for you.
500ug of Human BMP4
Recombinant Human Bone morphogenetic protein 4(BMP4)
CSB-YP002740HU >> Yeast
CSB-EP002740HU >> E.coli
CSB-BP002740HU >> Baculovirus
CSB-MP002740HU >> Mammalian cell
Expression region: 293-408aa; Full length of mature protein.
Tag information: EP is N-terminal 6xHis-SUMO-tagged, YP is N-terminal 6xHis-tagged; BP&MP are N-terminal 10xHis-tagged and C-terminal Myc-tagged
Target Protein Sequence:


Target Background

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Gene References into Functions
  1. The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression of Odontogenic Cyst and Tumors. PMID: 30079292
  2. We detected a haplotype-based interaction for BMP4 and IRF6 genes for expression of the orofacial cleft phenotype. Although the MDR methods indicate that the effect of interaction between these genes appears to be mild, the presence of specific haplotype combinations conferring a higher risk for NSCL/P reveals the possible combined role of these genes in the pathogenesis of this prevalent birth defect. PMID: 28133786
  3. Data show that bone morphogenetic protein 4 (BMP4) expression is associated and favored type II macrophage differentiation. PMID: 28928159
  4. MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating BMP-4. PMID: 29229885
  5. endothelial BMP4 controls leukocyte recruitment through a VE-cadherin-dependent mechanism and BMP4-induced inflammation might be involved in the pathogenesis of endothelial cell damage following successful resuscitation after cardiac arrest. PMID: 28755278
  6. Studied serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 levels were significantly elevated when compared to subjects with normal coronary arteries. PMID: 28605143
  7. BMP4 inhibits epithelial-mesenchymal transition of the retinal pigment epithelium. PMID: 27586653
  8. Potentially functional and tagging SNPs of BMP2 (rs170986, rs1979855, rs1980499, rs235768, rs3178250) and BMP4 (rs17563, rs4898820, rs762642) were genotyped in NSCLC. PMID: 28574846
  9. BMP4 polymorphic site rs4901474 (T>C) had an effect on hypertension; CC genotype carriers had a 1.48-fold risk for hypertension at the age of 50 years when compared with T-allele carriers PMID: 29390526
  10. High serum BMP4 levels are associated with postmenopausal osteoporosis. PMID: 28238166
  11. results indicate that the BMP4 rs17563 variant is likely to confer a protective effect against the occurrence of Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population. PMID: 29211286
  12. cardiomyocyte (CM) conditioned medium can trigger the recruitment of pro-inflammatory (M1) macrophages, through a mechanism that involves, in part, CM-derived BMP4. PMID: 26103914
  13. BMP4 participates in the regulation of invasion and migration by EC109/Taxol cells PMID: 28315766
  14. Bone morphogenetic protein 4 regulates expression of microRNAs miR-494 and miR-126-5p to control endothelial cell function in angiogenesis. PMID: 28124060
  15. BMP4 expression was significantly increased in HCC tissue, and was correlated with tumor de-differentiation and unfavorable prognosis. BMP4 promoted HCC EMT and was correlated with OXA resistance. PMID: 28987388
  16. Gene expression profiling showed that MuSK was required for the BMP4-induced expression of a subset of genes in myoblasts, including regulator of G protein signaling 4 (Rgs4). PMID: 27601729
  17. BMP4 levels are increased dramatically in individuals with impaired glucose tolerance and type 2 diabetes. PMID: 27524617
  18. The results suggest that selective RNA decay via TGF-beta and BMP4 signaling is critical for specifying the developmental fate of specific human embryonic cell lineages. PMID: 27304915
  19. Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG. PMID: 27931264
  20. Study shows that BMP4 is overexpressed in hepatocellular carcinoma (HCC) tissues and BMP4-induced ID2/CDKN1B signaling facilitates the proliferation of HCC. PMID: 28543546
  21. we demonstrate that expression of bone morphogenetic protein 4 (BMP-4) is universally upregulated in human colorectal cancer cells and tissues, resulting in activated BMP signaling PMID: 28611046
  22. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells PMID: 28640846
  23. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID: 26748560
  24. Meta-analysis to assess the effect of BMP4 rs17563 polymorphism on nonsyndromic cleft lip with or without cleft palate (NSCL/P) suggests that the C allele of BMP4 rs17563 may be a risk factor for NSCL/P among Asians and Caucasians, and may be a protective factor for NSCL/P in Brazilian population. PMID: 28767592
  25. this study identified BMP-4 as a potential molecular marker for predicting the invasion and progression of papillary thyroid carcinoma PMID: 28214211
  26. Bmp4 drives terminal differentiation into mature white rather than brown fat cells. Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner. PMID: 28425843
  27. Data suggest that serum BMP4 levels are associated with visceral adiposity and may play role in fat distribution; role of BMP4 in males and females may be different; visceral adiposity may predict serum BMP4 levels in females with obesity; serum BMP4 levels are decreased after GLP-1 receptor agonist (exenatide) treatment in obesity. This study was conducted in China. PMID: 28376799
  28. BMP4 is a potential cause of digital and eye abnormalities in familial dopa-responsive dystonia. PMID: 28558098
  29. BMP4 expression was significantly upregulated in esophageal adenocarcinoma and Barrett's esophagus. BMP4 incubation inhibited cell viability,induced cell migration adnd upregulated SNAIL2 expression. PMID: 27191723
  30. the data identify MxA as a novel stimulator of BMP4 and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases. PMID: 27875556
  31. The 6007C>T polymorphism of BMP-4, -66T>G polymorphism of OPN, and VDR-FokI polymorphism are the susceptible factors of spinal TB and indicators of the clinical severity. These three genes may collaborate in the development of spinal TB. PMID: 28376475
  32. The results suggest that Osterix plays an important role in increasing BMP- 4-induced Cx43 activity. PMID: 27498006
  33. inhibitory role on glucagon secretion, pancreatic alpha-cell growth, and expression of genes maintaining alpha-cell identity PMID: 27479530
  34. BMP4 promotes a phenotype change of an esophageal squamous epithelium via up-regulation of KLF4. PMID: 27693253
  35. Study demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced migration and invasion which stimulated breast cancer cell invasion and matrix degradation, in part, through MMP2 and MMP9 activity that is antagonized by Chrdl1. PMID: 26976638
  36. BMP4 GAAA (p=0.05) and GGGA (p=0.02) haplotypes were associated with peri-implantitis (p=0.03). Therefore, it may be concluded that BMP4 and FGF10 haplotypes are associated with peri-implantitis PMID: 27652695
  37. BMP4 inhibited ERalpha signaling by increasing the degradation of ERalpha, and that the expression of BMP4 itself was suppressed by estrogens. PMID: 27522322
  38. study shows that patients with CRA had high expression of BMP6 and hepcidin and low expression of s-HJV. BMP6 was found to be negatively correlated with s-HJV; both regulate hepcidin expression and play important roles in the development of anemia. PMID: 27051019
  39. we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes. PMID: 26684238
  40. BMP4 caused a trend towards accelerated metastasis formation, especially in bone. More work is needed to uncover the long-term effects of BMP4 and the clinical relevance of these findings. PMID: 26970275
  41. BMP4 is a direct thyroid hormone target and is involved in a positive autoregulatory feedback loop that modulates thyroid hormone signaling PMID: 26676745
  42. An up-regulated expression of BMP-4 and BMPR-II was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 and BMPR-II expressions were found to be correlated PMID: 26406943
  43. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. PMID: 26769046
  44. BMP4 gene is involved in the ATO regulation of adipogenic and osteogenic differentiation balance, which provides a new target for the treatment of AA PMID: 26215597
  45. Overexpression of the BMP4/SMAD4/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis. PMID: 26339396
  46. HIF-1alpha knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2+)]i. PMID: 25824146
  47. The effect of TGF-beta1 and BMP-4 on bone marrow-derived stem cell morphology on a novel bioabsorbable nanocomposite material. PMID: 24245787
  48. Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
  49. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines PMID: 26173116
  50. findings support a role of the BMP4 gene in the aetiology of non-syndromic CL/CLP and CP in the Latvian and Lithuanian populations. PMID: 25471993

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Involvement in disease
Microphthalmia, syndromic, 6 (MCOPS6); Non-syndromic orofacial cleft 11 (OFC11)
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
TGF-beta family
Tissue Specificity
Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Database Links

HGNC: 1071

OMIM: 112262

KEGG: hsa:652

STRING: 9606.ENSP00000245451

UniGene: Hs.68879

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