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| Code | CSB-YP004937HU1 |
| Product Type | Recombinant Protein |
| Size | US$2010 |
| Uniprot No. | P29965 |
| Relevance | Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | T-cell antigen Gp39 TNF-related activation protein Short name:TRAP Tumor necrosis factor ligand superfamily member 5 CD_antigen: CD154 Cleaved into the following 2 chains: CD40 ligand, membrane form CD40 ligand, soluble form |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | HRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL |
| Research Area | Immunology |
| Source | Yeast |
| Gene Names | CD40LG |
| Protein Names | Recommended name: CD40 ligand Short name= CD40-LAlternative name(s): T-cell antigen Gp39 TNF-related activation protein Short name= TRAP Tumor necrosis factor ligand superfamily member 5 CD_antigen= CD154Cleaved into the foll |
| Expression Region | 47-261aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 26.1kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Cytokine that binds to CD40/TNFRSF5 |
| Involvement in disease | Immunodeficiency with hyper-IgM, type 1 (HIGM1) |
| Subcellular Location | Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted |
| Protein Families | Tumor necrosis factor family |
| Tissue Specificity | Specifically expressed on activated CD4+ T-lymphocytes. |
| Database Links |
HGNC: 11935 OMIM: 300386 KEGG: hsa:959 STRING: 9606.ENSP00000359663 UniGene: Hs.592244 |
| Pathway |
NF-kappa B signaling pathway
T cell receptor signaling pathway |
CD40LG Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004937GA01HU | CD40LG Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA067336 | CD40LG Antibody | Human,Mouse | ELISA,WB |
| CSB-PA06005A0Rb | CD40LG Antibody | Human | ELISA |
| CSB-PA06005B0Rb | CD40LG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06005C0Rb | CD40LG Antibody, FITC conjugated | Human | ELISA |
| CSB-PA06005D0Rb | CD40LG Antibody, Biotin conjugated | Human | ELISA |
CD40LG Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP002211HU | Recombinant Human CD40 ligand(CD40LG),partial (Active) | E.coli |
| CSB-CF004937HU | Recombinant Human CD40 ligand(CD40LG) | in vitro E.coli expression system |
| CSB-RP060054h | Recombinant Human CD40 ligand(CD40LG),partial | E.coli |
| CSB-EP004937HU1 CSB-BP004937HU1 CSB-MP004937HU1 |
Recombinant Human CD40 ligand(CD40LG),partial | E.coli Baculovirus Mammalian cell |
CD40LG ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E04716h | Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
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