Recombinant Human CD40 ligand(CD40LG),partial

1. this study reports the clinical and CD40L genetic features of six Iranian hyper IgM syndrome patients PMID: 30081731
2. Overexpression of CD40L-WT/CD40L-M in CD40+ NSCLC cells increased SA-beta-gal staining activity and inhibited DNA synthesis and cell proliferation. PMID: 30078020
3. T cell-stimulated CLL cells actively recruited monocytes, and CD40L was identified as the responsible T-cell factor that mediated recruitment. PMID: 28971904
4. this study shows that decreased serum levels of soluble CD40L correlate in treated patients with Relapsing-Remitting Multiple Sclerosis PMID: 29050818
5. In conclusion, we described a new pathway of platelet-monocyte interaction, mediated by sCD40L and oxidative stress that may contribute to the progression of endothelial dysfunction during Shiga toxin 2-associated hemolytic uremic syndrome. PMID: 29068360
6. show that sCD40L/alpha5beta1 interaction leads to platelet activation as evaluated in the human whole blood PMID: 26719354
7. In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15]. PMID: 28333213
8. Study indicates that the rs1126535C/T polymorphism of CD154 gene was involved in the progression of Chinese SLE patients, probably by affecting the expression of CD154. PMID: 28550400
9. study found that plasma CD40L was associated with acute chest syndrome (ACS), and that sickle cell anemia (SCA)patients with a lifetime history of ACS (ACS+) presented significantly higher plasma CD40L and TSP-1 than patients who had never experienced ACS (ACS-) PMID: 28609750
10. this paper demonstrates importance of CD40/CD40L signaling on IL-10-producing regulatory B cells in Chinese children with Henoch-Schonlein purpura nephritis PMID: 27837410
11. Soluble CD40 ligand derived from serum is not correlated with early stage of multiple sclerosis. PMID: 28619427
12. Analysis of the early events after receptor engagement revealed that both TNF and CD40L activate the classical NF-kappaB pathway, and confirm activation of the alternative by the latter. Furthermore, using genetic and pharmacological inhibition of the classical pathway we show that activation of the alternative occurs independently of the former. This reveals insights into NF-kappaB signaling by CD40L and TNF in endoth... PMID: 29183724
13. CD40L, more than IL-6, or TNF-alpha, constitutes a predictor to explain polycystic ovary syndrome and associated features PMID: 27572328
14. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis. PMID: 29155846
15. Plasma sCD40L levels were elevated in systemic lupus erythematosis patients who had positive anti-phospholipid antibodies and experienced arterial thrombosis, suggesting that enhanced release of sCD40L through platelet activation presumably by aPL could contribute to the development of atherothrombotic disease. PMID: 28421990
16. Higher concentrations of CD40L in patients with limited cutaneous form in our study might suggest a role for CD40/CD40L pathway in vascular pathology of systemic sclerosis. PMID: 27392528
17. we also report for the first time that the rs1126535 C allele (CD40L gene) may predict a worse response after gastric bypass in morbidly obese patients PMID: 27681093
18. Serum levels of sCD40L and MMP-9 are associated with the stability of carotid plaques. PMID: 28642174
19. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling PMID: 28461568
20. data suggest that therapeutic CD40-CD40L blocking agents may prove efficacious not only in early and established rheumatoid arthritis (RA), but also in inhibiting the progression of the disease from arthralgia or undifferentiated arthritis to RA PMID: 28455435
21. CD4(+) T cells that coexpress CD57 and CD154, which are exclusively present in cytomegalovirus-positive individuals. PMID: 27566833
22. Serum CD40L levels were elevated in both neuromyelitis optica and multiple sclerosis patients. PMID: 27725124
23. plasma PGE2 is correlated with the prevention of IVIG resistance and CAL formation through CD40L in KD PMID: 27525421
24. This study provides the first evidence that human circulating group 2 innate lymphoid cells can express CD154 and stimulate the production of IgE by B lymphocytes through IL-25/IL-33 stimulation or TLR triggering PMID: 27576126
25. data also demonstrated that the CD154-triggered inhibition of the Fas-mediated cell death response was dependent on a suppression of caspase-8 cleavage, but independent of de novo protein synthesis or alterations in Fas expression on cell surface. PMID: 27391025
26. These results suggest soluble CD40L could have a prognostic value in ST-elevation myocardial infarction patients. PMID: 27172386
27. persistence of helper T-cell-derived CD40L on or in B cells could permit sustained CD40 signaling enabling survival and proliferation of antigen-presenting B cells following brief interactions with helper T cells in vivo in germinal centers. PMID: 27753080
28. These results demonstrate the feasibility of engineered nuclease-directed gene repair to restore endogenously regulated CD40L, and the potential for its use in T-cell therapy for X-HIGM syndrome. PMID: 26903548
29. Hypertensives showed significantly enhanced soluble CD40L levels compared to normotensive controls PMID: 27090943
30. The levels of sCD40l have no influence on survival or cardiovascular events and mortality in haemodialysis patients in a long-term follow-up PMID: 27295448
31. CD40L gene polymorphism was found to be associated with severe falciparum malaria in Indian population especially in severe malarial anaemia. PMID: 28352049
32. While CD40 expression tends to be relatively high in the peritumoral dermis of epithelial carcinomas, the expression of CD40L in mast cells is low in the same peritumoral area, compared with the opposite findings in psoriasis and actinic keratosis. PMID: 28267402
33. Increased serum sCD40L levels may be related to angiogenesis in patients with multiple myeloma (MM). This protein has potential clinical usefulness in MM and may be considered as an additional prognostic marker. The correlation of sCD40L with beta-thromboglobulin may indicate that in patients with MM sCD40L derives from activated platelets. PMID: 27243341
34. Primary Aldosteronism is related to platelet activation, expressed as higher plasma values of soluble CD40L and soluble P-selectin values. PMID: 27101095
35. Given the crucial role of sCD40L, this haplotype study in a transfusion model may be helpful to further determine the role of haplotypes in inflammatory clinical settings. PMID: 27094978
36. Overexpression of CD154 on CD4(+)T cells is unlikely to be central to the pathogenesis of idopathic thrombocytopenic purpura, and other immune dysfunctions should be targeted for therapy purposes. PMID: 26183367
37. the serum levels of the soluble factors sCD40L and CXCL1 are not associated with endometriosis and are not suitable as biomarkers for disease diagnosis. PMID: 27190986
38. Increased sCD40L plasma levels are associated with the presence of insulin resistance and not the state of glucose tolerance. PMID: 26934129
39. we report that Kv1.3-NPs reduced NFAT activation and CD40L expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive. PMID: 26994905
40. mCD40L-induced cell death mediated by NORE1A expression appeared to be independent of mCD40L-induced cell death mediated by sustained JNK activation since NORE1A inhibition did not affect JNK phosphorylation and vice versa PMID: 26986513
41. diagnostic value of soluble CD40 ligand (sCD40L) and vascular endothelial growth factor (VEGF) for Alzheimer's disease PMID: 26706786
42. Study allows identify significant different genetic heterogeneity between two investigated populations (France and Tunisia) and revealed discrepancies in the prevalence of CD40LG polymorphisms that may be explained by ethnic and geographic differences. PMID: 26577033
43. concentrations of the C-reactive protein, myeloperoxidase and soluble CD40 ligand taken from peripheral vein were closely similar to the concentration found in coronary blood of ACS patients PMID: 26576922
44. Studies suggest that the CD40/CD154 pathway represents a promising potential therapeutic target for the prevention of transplantation rejection. PMID: 26268734
45. Three single-nucleotide polymorphisms (SNPs) of the TLR8, CD40LG and IRAK1 genes on the X chromosome were genotyped. PMID: 26043172
46. plasma soluble CD40L levels are reduced by antiplatelet therapy with clopidogrel, but not associated with long-term ischemic outcomes in unselected consecutive aspirin-treated patients undergoing cardiac catheterization. PMID: 26237513
47. The study findings showed that plasma sCD40L, fetuin-A, and PAPP-A levels are associated with carotid plaque formation and instability. PMID: 26214492
48. CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells. PMID: 26313915
49. CD40 ligand induces von Willebrand factor release from endothelial cells PMID: 25608503
50. Higher plasma soluble CD40L levels on presentation are associated with clinical severity and have potential to be a good prognostic biomarker of aneurysmal subarachnoid hemorrhage. PMID: 25944664
51. sCD40L should have the potential to be a prognostic biomarker for nasopharyngeal carcinoma PMID: 26032866
52. time changes of sCD40L over 1 month after myocardial infarct onset were associated with G894T eNOS polymorphism and with the VEGF concentrations, but not to the platelet CD62P expression PMID: 26279254
53. Data found higher serum sCD154 levels in patients with severe malignant middle cerebral artery infarction compared to controls and correlated with mortality. PMID: 26030673
54. A novel CD40LG deletion causes the hyper-IgM syndrome with normal CD40L expression in a 6-month-old child PMID: 25752457
55. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases. PMID: 25839125
56. Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method. PMID: 24905579
57. CD40L engagement activates the PI3K pathway to inhibit HSV-1 propagation by an autophagy-independent mechanism. PMID: 25765994
58. study identified two patients with hyper-IgM syndrome, with mutations of the CD40LG gene (Patient 1 de novo mutation, Patient 2 X-linked transmission from carrier mother) PMID: 23010537
59. Plasma CD40L was significantly higher in type 2 diabetes patients than in controls. PMID: 25037197
60. Elevated soluble CD40L levels predict recurrent stroke in patients with minor stroke and transient ischemic attack. PMID: 26012640
61. A striking case for diagnosis of CD40L deficiency at the age of 33 years in the proband has been described, along with the diagnoses of his two healthy sons. PMID: 21958324
62. significantly increased lipid deposition and foam cell formation associated with upregulation of scavenger receptor type A and CD36 PMID: 25825037
63. Human osteoclasts are inducible immunosuppressive cells in response to T cell-derived IFN-gamma and CD40 ligand in vitro. PMID: 24916315
64. Data suggest that increased frequency of circulating follicular helper T cells in lupus patients is associated with excess B-cell help and autoantibody production in a CD40 antigen ligand (CD40L) dependent manner. PMID: 25748125
65. A higher percentage of CD3(+)CD154(+) T lymphocytes could predict clinical efficacy of SpondyloArthritis patients with TNF-alpha treatment. PMID: 24912812
66. The expression of plasma CD40L was increased in patients with pelvic inflammatory disease, and could serve as a diagnostic marker. PMID: 25192781
67. Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L. PMID: 25375372
68. We demonstrated that B cells with potent antigen presentation capacity can be generated and expanded by use of a non-xenogeneic form of CD40L that could be implemented in future human clinical settings. PMID: 25287602
69. Serum sCD40L levels in non-surviving patients with severe brain trauma injury are higher than in surviving ones, and there are an association between serum sCD40L levels and brain trauma injury severity and mortality. PMID: 25123332
70. Studied the effect of drug-eluting stent (DES) implantation on soluble CD40 ligand (sCD40L) levels in patients with stable coronary artery disease undergoing stent replacement. PMID: 24351940
71. Based on CD137 or CD154 expression. PMID: 25367298
72. CD154 functions as a trimer and may bind concomitantly to two receptors of the same or different family biologically activating cells expressing both receptors. PMID: 25403978
73. It is a promising serological marker for hepatocellular carcinoma PMID: 24635038
74. The possible role of MMP-9 and MMP-2 on the expression of soluble CD154 (sCD154) and membrane-bound isoform of the CD154 in Iranian multiple sclerosis patients, was examined. PMID: 24751386
75. Study suggests that soluble CD40 ligand and urotensin II likely play a role in the pathogenesis of slow coronary flow. PMID: 25648034
76. Serum sCD40L is correlated with immunosuppression and angiogenesis in PDAC carcinogenesis/progression, and is a promising diagnostic and prognostic biomarker for PDAC superior to CA19-9 and CEA PMID: 24745825
77. we report results obtained on their effect in suppressing both the TNFa- and the CD40L-induced activation of NF-kappaB in sensor cells that contain an NF-kappaB-inducible SEAP construct. PMID: 24747770
78. Ten distinct CD40L mutations (six novel) have been identified in a small cohort of Chinese patients with hyper-IgM syndrome type 1. PMID: 24768948
79. This study demonistrated that CD40LG deficiency in patient with ataxia telangiectasia. PMID: 24631270
80. The anti-apoptotic phenotype of chronic lymphocytic leukemia involves a sensitized response for IL4 dependent STAT6 phosphorylation, and an activation of NF-kB signaling due to an increased affinity of sCD40L to its receptor. PMID: 24828787
81. atrial fibrillation patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation PMID: 24771985
82. TSLP synergized with CD40 ligand to promote dendritic cell activation and pathogenic IL-23 production by primary blood and skin dendritic cells. PMID: 24910175
83. In chronic hepatitis C, the hepatocyte infection rate influences OSMRb expression levels, which also show variability among patients. PMID: 24418171
84. The CD40/CD40L system is involved in the process of post-stroke epilepsy. PMID: 24657679
85. studies demonstrated a novel mutation in CD40L, which, to our knowledge, has not been reported previously. PMID: 25268346
86. Human induced pluripotent stem cells expressing CD40 ligand prolonged survival in a metastatic breast cancer model. PMID: 24972599
87. higher serum levels in osteosarcoma, Ewing sarcoma and chondrosarcoma patients with primary bone tumors PMID: 24375064
88. Data indicate that single nucleotide polymorphisms (SNPs) in two X-linked genes, glucose-6-phosphate dehydrogenase (G6PD) and CD40L, were associated with altered risk of severe malaria in females but not in males. PMID: 23144702
89. Data indicate higher frequency of CD154+ T cells in grass-allergic individuals compared to healthy controls, but this difference was not evident following stimulation with cat allergen. PMID: 24188324
90. It seems that DPU is associated with increased systemic release of sCD40L, which is believed to derive predominantly from activated platelets. PMID: 24236294
91. CD40L may contribute to atherogenesis via PRKCB by activating endothelial cells and recruiting monocytes to them. PMID: 24039784
92. Platelet-derived microparticles carrying soluble CD40L accumulate in apheresis platelet concentrates during 5 days of storage, are capable of priming the neutrophil-activated respiratory burst and might cause transfusion-related acute lung injury. PMID: 24138005
93. In patients with chest pain, an increased urine IgM excretion is associated with coronary artery disease. PMID: 24028208
94. Greater concentrations of sCD40L and TNF-B at sites of stenosis suggest that these cytokines play a role in the pathogenesis of symptomatic SFA disease. PMID: 23299818
95. The results indicate that elevated CD40L expression on peripheral blood monocytes is associated with carotid atherosclerosis and plaque instability. PMID: 23561892
96. The majority of patients (10/14; 71.4%) with CD40L mutations except (Thr254Met) and an ataxia-telangiectasia patient had the severe form of Hyper IgM syndrome phenotype. PMID: 23538518
97. Data indicate taht inducible membrane-bound CD40L on CD4(+) T cells is increased in patients with primary Sjogren's syndrome (pSS) but was not related to epigenetic deregulation by demethylation patterns of the regulatory regions of CD40L. PMID: 24117612
98. in vivo biochemical or genetic inhibition of NFATc2 activity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulatory pathway of inflammatory and immunomodulatory activity in platelets PMID: 24106272
99. sCD40L is elevated in the plasma and cerebrospinal fluid of HIV infected, cognitively impaired individuals and has an important role as an inflammatory mediator in the pathogenesis of HIV-Associated Neurocognitive Disorders PMID: 23555843
100. In addition to BCR signaling, activated T cells might contribute to CLL cell proliferation via CD40L and IL-21 expression and signaling. PMID: 24014238

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HGNC: 11935

OMIM: 300386

KEGG: hsa:959

STRING: 9606.ENSP00000359663

UniGene: Hs.592244