CD40LG Antibody

Datasheet
Code CSB-PA004937GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P29965
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human CD40LG
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias CD40 ligand;CD40LG;CD154;CD40L;HIGM1;IGM;IMD3;T-BAM;TNFSF5;TRAP;gp39;hCD40L ;
Immunogen Species Homo sapiens (Human)
Target Names CD40LG
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
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Function Cytokine that binds to CD40/TNFRSF5
Involvement in disease Immunodeficiency with hyper-IgM, type 1 (HIGM1)
Subcellular Location Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted
Protein Families Tumor necrosis factor family
Tissue Specificity Specifically expressed on activated CD4+ T-lymphocytes.
Database Links

HGNC: 11935

OMIM: 300386

KEGG: hsa:959

STRING: 9606.ENSP00000359663

UniGene: Hs.592244

Pathway NF-kappa B signaling pathway
T cell receptor signaling pathway

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