Recombinant Human CD40 ligand(CD40LG),partial

Code CSB-RP060054h
Product Type Recombinant Protein
Size US$1726
Uniprot No. P29965
Relevance Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias T-cell antigen Gp39TNF-related activation protein ;TRAPTumor necrosis factor ligand superfamily member 5; CD154
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence HRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGL
Research Area Cardiovascular
Source E.coli
Gene Names CD40LG
Expression Region 47-258aa
Tag Info N-terminal GST-tagged
Mol. Weight 50.8kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Cytokine that binds to CD40/TNFRSF5
Involvement in disease Immunodeficiency with hyper-IgM, type 1 (HIGM1)
Subcellular Location Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted
Protein Families Tumor necrosis factor family
Tissue Specificity Specifically expressed on activated CD4+ T-lymphocytes.
Database Links

HGNC: 11935

OMIM: 300386

KEGG: hsa:959

STRING: 9606.ENSP00000359663

UniGene: Hs.592244

Pathway NF-kappa B signaling pathway
T cell receptor signaling pathway

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