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| Product Type | Recombinant Protein |
| Uniprot No. | P25942 |
| Species | Homo sapiens (Human) |
| Gene Names | CD40 |
| Protein Names | Recommended name: Tumor necrosis factor receptor superfamily member 5Alternative name(s): B-cell surface antigen CD40 Bp50 CD40L receptor CDw40 CD_antigen= CD40 |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | This protein is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| HGNC | 24929 |
| RGD | 1304867 |
| MGI | 1922901 |
| Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
| Involvement in disease | Immunodeficiency with hyper-IgM 3 (HIGM3) |
| Subcellular Location | Isoform I: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform II: Secreted |
| Tissue Specificity | B-cells and in primary carcinomas. |
| Database Links |
HGNC: 11919 OMIM: 109535 KEGG: hsa:958 STRING: 9606.ENSP00000361359 UniGene: Hs.472860 |
| Pathway |
NF-kappa B signaling pathway
Toll-like receptor signaling pathway |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial,Yeast |
| Code | CSB-YP004936HU1 |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR |
| Expression Region | 21-193 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial,E.coli |
| Code | CSB-EP004936HU1 |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR |
| Expression Region | 21-193 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial,Baculovirus |
| Code | CSB-BP004936HU1 |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR |
| Expression Region | 21-193 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial,Mammalian cell |
| Code | CSB-MP004936HU1 |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR |
| Expression Region | 21-193 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
CD40 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004936GA01HU | CD40 Antibody | Human | ELISA,WB |
| CSB-PA176134 | Phospho-CD40 (Thr254) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA001455 | CD40 Antibody | Human,Mouse,Monkey | WB,IHC,ELISA |
| CSB-PA080031 | Phospho-CD40 (T254) Antibody | Human,Mouse | WB,ELISA |
| CSB-PA215588 | CD40 Antibody | Human,Mouse | ELISA,IHC |
CD40 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004936LA01HU | CD40 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA004936LB01HU | CD40 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004936LC01HU | CD40 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004936LD01HU | CD40 Antibody, Biotin conjugated | Human | ELISA |
CD40 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF004936HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40) | in vitro E.coli expression system |
CD40 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E15854h | Human soluble CD40 ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
Recombinant Human DNA-(apurinic or apyrimidinic site) lyase(APEX1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Melanoma-associated antigen 10(MAGEA10)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Proteasome subunit beta type-8(PSMB8)
Express system: E.coli
Species: Homo sapiens (Human)
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