CD40, also known tumor necrosis factor receptor superfamily member 5 ( TNFRSF5), is a 45-50 kDa type I glycoprotein and belongs to tumor necrosis factor receptor (TNFR) superfamily. CD40 is widely expressed by antigen presenting cells (APCs) or all stages of B cells. The ligand of CD40 is CD154 (also known as CD40L), which is a type II transmembrane protein with a variable molecular weight between 32-39 kDa. CD40L is mainly expressed on activated CD4+ T cells and is a member of TNF superfamily. Like many other members of the TNFR superfamily, CD40 are also divided into membrane-anchored CD40 (mCD40) and soluble CD40 (sCD40). sCD40 retains the ability to bind to CD40L, and is an important negative regulator of the effect of CD40-CD40L.
CD40/CD40L interaction plays an important role in immune regulation. CD40/CD40L belongs to receptor-ligand families: TNFR and TNF family. Families are characterized by structural homologies, clustered chromosome location, and shared signal transduction pathways. In addition, families usually overlap biological events like cell growth, differentiation and death. The interaction of CD40-CD40L can produce a wide range of biological effects, which are closely related to the occurrence, development and immune diseases of atherosclerosis, making it a promising therapeutic target for these diseases. Animal experiments and in vitro experiments show that anti-CD40 monoclonal antibody has obvious curative effect on the treatment of AS, tumor and post-transplant rejection.
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Validated Data
Greater than 92% as determined by SDS-PAGE.
Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC50 is 3.112-3.858 ng/ml.
Human CD40 protein captured on COOH chip can bind Human CD40L protein with an affinity constant of 2.06 nM as detected by LSPR Assay.
The following CD40 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CD40 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004936GA01HU | CD40 Antibody |
Human | ELISA,WB |
CSB-PA176134 | Phospho-CD40 (Thr254) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA001455 | CD40 Antibody |
Human,Mouse,Monkey | WB, IHC, ELISA |
CSB-PA080031 | Phospho-CD40 (T254) Antibody |
Human,Mouse | WB, ELISA |
CSB-PA215588 | CD40 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA004936LA01HU | CD40 Antibody |
Human, Mouse | ELISA, WB, IF |
CSB-PA004936LB01HU | CD40 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA004936LC01HU | CD40 Antibody, FITC conjugated |
Human | |
CSB-PA004936LD01HU | CD40 Antibody, Biotin conjugated |
Human | ELISA |
CD40 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004936HU1 CSB-EP004936HU1 CSB-BP004936HU1 CSB-EP004936HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF004936HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40) |
in vitro E.coli expression system |
CSB-AP005171HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) |
Mammalian cell |
CSB-AP005181HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) |
Mammalian cell |
CSB-MP004936HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) |
Mammalian cell |
CD40 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP636713BO CSB-EP636713BO CSB-BP636713BO CSB-MP636713BO CSB-EP636713BO-B |
Recombinant Bovine Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
Code | Product Name | Source |
---|---|---|
CSB-YP659466CYL CSB-EP659466CYL CSB-BP659466CYL CSB-MP659466CYL CSB-EP659466CYL-B |
Recombinant Callithrix jacchus Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP675871HO CSB-EP675871HO CSB-BP675871HO CSB-MP675871HO CSB-EP675871HO-B |
Recombinant Horse Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP767175DO CSB-EP767175DO CSB-BP767175DO CSB-MP767175DO CSB-EP767175DO-B |
Recombinant Dog Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP851448PI CSB-EP851448PI CSB-BP851448PI CSB-MP851448PI CSB-EP851448PI-B |
Recombinant Pig Tumor necrosis factor receptor superfamily member 5(CD40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004936MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 5(Cd40) |
in vitro E.coli expression system |
CSB-YP004936MO1 CSB-EP004936MO1 CSB-BP004936MO1 CSB-MP004936MO1 CSB-EP004936MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 5(Cd40),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL004936MO | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit |
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