CD40 (also known as Bp50) is a cell surface protein that belongs to the tumor necrosis factor receptor superfamily (TNF receptor superfamily). CD40 is a single-chain transmembrane protein consisting of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. Its extracellular domain can bind to its ligand CD40L (CD40 ligand), triggering signal transduction. CD40 is a critical regulatory molecule in the immune system, playing a significant role in humoral immune responses, the formation of immune memory, and immune regulation. Its functions extend to various aspects, including B cell activation, antigen presentation, and inflammation regulation. Therefore, research on CD40 is of great value in understanding how the immune system responds to infections, autoimmune diseases, cancer, and other diseases. Furthermore, CD40 signal transduction is extensively studied in immunotherapy research to develop new therapeutic approaches for enhancing or suppressing specific immune responses.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC50 is 3.112-3.858 ng/ml.
Activity: Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
The following CD40 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CD40 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004936GA01HU | CD40 Antibody |
Human | ELISA,WB |
CSB-PA176134 | Phospho-CD40 (Thr254) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA001455 | CD40 Antibody |
Human,Mouse,Monkey | WB, IHC, ELISA |
CSB-PA080031 | Phospho-CD40 (T254) Antibody |
Human,Mouse | WB, ELISA |
CSB-PA215588 | CD40 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA004936LA01HU | CD40 Antibody |
Human, Mouse | ELISA, WB, IF |
CSB-PA004936LB01HU | CD40 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA004936LC01HU | CD40 Antibody, FITC conjugated |
Human | |
CSB-PA004936LD01HU | CD40 Antibody, Biotin conjugated |
Human | ELISA |
CD40 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004936HU1 CSB-EP004936HU1 CSB-BP004936HU1 CSB-EP004936HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF004936HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40) |
in vitro E.coli expression system |
CSB-AP005171HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) |
Mammalian cell |
CSB-AP005181HU | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) |
Mammalian cell |
CSB-MP004936HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) |
Mammalian cell |
CD40 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP636713BO CSB-EP636713BO CSB-BP636713BO CSB-MP636713BO CSB-EP636713BO-B |
Recombinant Bovine Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
Code | Product Name | Source |
---|---|---|
CSB-YP659466CYL CSB-EP659466CYL CSB-BP659466CYL CSB-MP659466CYL CSB-EP659466CYL-B |
Recombinant Callithrix jacchus Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP675871HO CSB-EP675871HO CSB-BP675871HO CSB-MP675871HO CSB-EP675871HO-B |
Recombinant Horse Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP767175DO CSB-EP767175DO CSB-BP767175DO CSB-MP767175DO CSB-EP767175DO-B |
Recombinant Dog Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP851448PI CSB-BP851448PI CSB-MP851448PI CSB-EP851448PI-B |
Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004936MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 5 (Cd40) |
in vitro E.coli expression system |
CSB-YP004936MO1 CSB-EP004936MO1 CSB-BP004936MO1 CSB-MP004936MO1 CSB-EP004936MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 5 (Cd40), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD40 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL004936MO | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit |
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