CD40

CD40 (also known as Bp50) is a cell surface protein that belongs to the tumor necrosis factor receptor superfamily (TNF receptor superfamily). CD40 is a single-chain transmembrane protein consisting of an extracellular domain, a transmembrane domain, and a cytoplasmic domain. Its extracellular domain can bind to its ligand CD40L (CD40 ligand), triggering signal transduction. CD40 is a critical regulatory molecule in the immune system, playing a significant role in humoral immune responses, the formation of immune memory, and immune regulation. Its functions extend to various aspects, including B cell activation, antigen presentation, and inflammation regulation. Therefore, research on CD40 is of great value in understanding how the immune system responds to infections, autoimmune diseases, cancer, and other diseases. Furthermore, CD40 signal transduction is extensively studied in immunotherapy research to develop new therapeutic approaches for enhancing or suppressing specific immune responses.

Popular Product

● Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-MP004936HU1

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC₅₀ is 3.112-3.858 ng/ml.

LSPR

Activity: Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.