Recombinant Mouse Guanine nucleotide-binding protein G (i) subunit alpha-2 (Gnai2)

1. In conclusion, Galphai2 deficiency in erythrocytes confers partial protection against suicidal cell death. PMID: 27499046
2. This study reveals how RGS proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking. PMID: 28235863
3. this study shows that Galphai2 controls arrest in response to chemokine stimulation of neutrophils PMID: 26976957
4. In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning. PMID: 27787898
5. Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy. PMID: 26972746
6. RGS proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM sleep PMID: 26564126
7. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing. PMID: 26662512
8. Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy. PMID: 26464333
9. An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. PMID: 26373672
10. Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo. PMID: 25944935
11. Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A) expression in hematopoietic cells results in a loss of GTP-binding protein alpha subunits Galphai2, Galphai3, and Galphaq. PMID: 26232433
12. Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 and Galphai3, indicating important roles for both Galphai isoforms. PMID: 24858945
13. RGS protein/Galphai2 interactions have an essential role in B lymphocyte-directed cell migration and trafficking. PMID: 25617475
14. Data (including data from knockout mice) suggest that Gnai2 in islet beta-cells is necessary for up-regulation of insulin secretion in response to high glucose in presence of L-arginine or L-ornithine. PMID: 25205820
15. The absence of Galphai2 and Galphai3 in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract. PMID: 23977324
16. Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase -dependent manner PMID: 24298018
17. Galphas- and Galphai2-mediated signaling in the sinoatrial node is important in the reciprocal regulation of heart rate through the autonomic nervous system. PMID: 23697798
18. Galphai2-deficient mice spontaneously develop colitis and colonic neoplasms the severity of which are determined by the interplay between Th1 and Th2 cell pathways. PMID: 22962436
19. Go2alpha protein subunit regulates axonal growth and branching and may increase Rap1GAP activity, thereby effecting the Rap1 activation/deactivation cycle. PMID: 23373526
20. Galphai2 is required for endothelial neutrophil transmigration but not neutrophil chemotaxis and adhesion. PMID: 23225882
21. These studies support our hypothesis that G-alpha(i2) proteins are novel negative regulators of Toll-like receptor activation. PMID: 22581266
22. RGS proteins establish a threshold for Galpha(i2) activation, helping to coordinate desensitization mechanisms during inflammation. PMID: 22966200
23. A quantitative study of the mechanisms behind thymic atrophy in Galphai2-deficient mice during colitis development. PMID: 22590596
24. Galphai2 is an essential Galphai protein required for inflammation-induced migration of monocytes and macrophages in Galphai2- or Galphai3-deficient mice. PMID: 22706085
25. analysis of Galphai2- and Galphai3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes PMID: 21966394
26. Demonstrate that signalling through Gai2 protects the heart from ischaemic injury and that this process is modulated by endogenous RGS proteins. PMID: 21349876
27. Cecal ligation and puncture -induced plasma TNFalpha, IL-6, bacterial load in peritoneal fluid, blood and lung tissue and lung and liver MPO activity were significantly increased in Galphai2 (-/-) compared to WT mice. PMID: 21255617
28. Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs. PMID: 20508603
29. Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation. PMID: 20607800
30. The absence of inhibitory G-protein signaling mediated through Galpha(i2) is a substrate for ventricular arrhythmias. PMID: 20495013
31. G alpha i2(-/-) mice are deficient in B-1a B cells, splenic marginal zone B cells, and their immediate precursor, T2 B cells, with resultant in vitro functional deficiency in LPS-induced proliferation and IL-10 production. PMID: 12574334
32. Gi2 has a role in regulating mitogenic activity in the neural progenitor cells of developing brain PMID: 15272018
33. Alveolar macrophages use a Galphai2-dependent signal for modulating the two opposing Fc gamma receptors, FcgammaRIIB and FcgammaRIII, in the initiation of the inflammatory cascade in the lung Arthus reaction. PMID: 15728518
34. Constitutively active Galphai2 occludes the transient suppression of synaptic transmission by mGluR2. PMID: 16606834
35. Loss of Regulators of G protein signaling (RGS) actions at Galpha(i2) produces a dramatic and pleiotropic phenotype which is more evident than the phenotype seen for individual RGS protein knockouts. PMID: 16943428
36. These data demonstrate that G(i2) and G(i1/3) proteins are both involved and differentially regulate splenocyte inflammatory cytokine and chemokine production in a highly Gi isoform specific manner in response to LPS and Gram-positive microbial stimuli. PMID: 16962188
37. Galphai2 signaling events are not required for the development of the protective immune responses against S. stercoralis; however, Galphai2 is essential for the recruitment of neutrophils required for host-dependent killing of larvae. PMID: 17242370
38. This study details distinct G alpha(i2) and G alpha(i3) effects on chemokine receptor CXCR3-mediated signaling. PMID: 17289675
39. Gnai2 knockout mice show significantly reduced intestinal IL-11 production. Suggest MAP kinases, PGE2 and cAMP mediated signaling involved. PMID: 17332478
40. specific Galpha(i2)-mediated signaling between endothelial cells and leukocytes is required for the extravasation of leukocytes and for tissue-specific accumulation PMID: 17360531
41. Ghrelin attenuates glucose-induced insulin release via pertissigen-sensitive Galpha(i2)-mediated activation of potassium channels. PMID: 17575083
42. Gnai2-deficient T cells exhibit significant defects in chemokine receptor signaling and illustrate how signals that modulate the level of Galphai2 present in lymphocytes directly affect the capacity of lymphocytes to respond to chemokines. PMID: 17579064
43. Neutrophil Galpha(i2) is necessary for chemokine-induced arrest. PMID: 17699741
44. Transgenic mice on a high fat diet which have this gene exhibit enhanced insulin sensitivity and increased glucose tolerance. PMID: 17928396
45. results indicate that the upregulation of Gi2 in ischemic myocardium appears to be protective in inducing cell survival pathways to prevent myocyte death in response to ischemia/reperfusion injury PMID: 18316484
46. Absence of either Galphai2 or Galphai3 significantly abrogated thymic homing, with an effect of Galphai3 being greater than that of Galphai2. PMID: 18501427
47. These observations underscore interplay between Galphai2 and Galphai3 and potentially provide a novel strategy to prevent GVHD by blocking T cell homing at early stages and T effector cell trafficking at later time points. PMID: 18521956
48. Report role of Gnai2 in the control of in vivo heart rate dynamics. PMID: 18832081
49. In Galphai2(-/-) and interleukin-10(-/-) transgenic mice susceptible to immune-mediated colitis and inflammation-associated adenocarcinoma, similar levels of peripheral leukocyte and erythroblast genotoxicity were also observed. PMID: 19487293
50. Young Gialpha2-/- colonic epithelium has normal MMR expression but selectively loses MLH1 and consequently PMS2 expression following inflammation. PMID: 19638594

Show More

Hide All

KEGG: mmu:14678

STRING: 10090.ENSMUSP00000057543

UniGene: Mm.196464