Product Details

Purity

>85% (SDS-PAGE)

Target Names

Vav3

Uniprot No.

Q9R0C8

Alternative Names

Vav3; Guanine nucleotide exchange factor VAV3; VAV-3

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.

Gene References into Functions

Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis. PMID: 25501893
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity PMID: 23931752
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. PMID: 22692505
study discloses an essential and nonredundant role for this Vav family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates PMID: 20926682
Vav3 is a bona fide Ahr target that is in charge of a limited subset of the developmental and physiological functions controlled by this transcriptional factor. PMID: 21115475
These results indicate that Vav3 function contributes to the timely developmental progression of the cerebellum. PMID: 20089829
Genetic mapping, sequencing, and evidence of gene expression indicate that alteration of VAV3 expression is an etiological factor in the development of autoimmune pancreatic beta-cell destruction in nonobese diabetic (NOD) mice. PMID: 20363978
Vav3, a Rho family guanine nucleotide exchange factor, is essential for stimulated osteoclast activation and bone density in vivo PMID: 15711558
Crucial role of Vav3 in the regulation of the sympathetic nervous system (SNS) and cardiovascular physiology, reveal a signaling pathway that could be involved in the pathophysiology of human disease states involving sympathetic hyperactivity. PMID: 16767097
Vav3 overexpression in the prostate epithelium enhanced both the androgen receptor signaling axis and NF-kappaB-mediated pathway, which potentially contributed to the development of nonbacterial prostatitis and prostate cancer PMID: 18676865
TGF-beta(1) deficiency in Vav3(-/-) macrophages was causally responsible for the healing defect PMID: 19147786
By modulating Vav3-dependent signaling, dioxin receptor could regulate cell shape, adhesion, and migration under physiological conditions and, perhaps, in certain pathological states PMID: 19158396
central role of SLP-76/Vav3 association in osteoclastic resorption PMID: 19592646

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Tissue Specificity

Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.

Database Links

KEGG: mmu:57257

STRING: 10090.ENSMUSP00000036270

UniGene: Mm.282257

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Recombinant Mouse Guanine nucleotide exchange factor VAV3 (Vav3), partial

Product Details

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Target Background

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