Recombinant Mouse Netrin receptor DCC (Dcc), partial

1. this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane. PMID: 29546593
2. Local spinal cord defects following loss of Dcc cause a hopping gait in mice and may contribute to mirror movements in humans. PMID: 28691197
3. Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. PMID: 28341853
4. We show, for the first time, that dopamine axons continue to grow from the striatum to the PFC during adolescence. Importantly, we discover that DCC, a guidance cue receptor, controls the extent of this protracted growth by determining where and when dopamine axons recognize their final target. PMID: 28720317
5. role in normal innervation of the peripheral vestibular system PMID: 27539716
6. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. PMID: 28701345
7. Together, these results demonstrate that the production of DCC splice variants controlled by NOVA has a crucial function during many stages of commissural neuron development. PMID: 27223328
8. Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats. PMID: 28108253
9. Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord. PMID: 27784329
10. Results suggest that Dcc plays an important role in the developmental formation of peripheral and central auditory circuits, and its mutation may contribute to sensorineural hearing loss. PMID: 27040640
11. dcc haploinsufficient mice acquire intracranial self-stimulation behavior and that the parameters of the stimulation are comparable to those observed in wild-type littermates; reduced expression of dcc may dampen the abuse potential of cocaine PMID: 26005129
12. Identified the Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth. PMID: 25947198
13. suggest that DCC signaling functions through NCK1 and NCK2 and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait PMID: 25913325
14. Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1-induced axon branching. PMID: 25754961
15. Overall, these findings suggest that commissural axons use distinct mechanisms to navigate in different CNS regions. PMID: 26290247
16. Data indicate the roles of Slit1/Robo1 and Netrin1/DCC signals in positioning motor neuron cell bodies. PMID: 25530182
17. These data demonstrate robust cardioprotective effect of netrin-1 in vivo, as shown by reduced infarct size and improved cardiac function mediated by netrin-1 receptor DCC. PMID: 24928309
18. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. PMID: 24739528
19. DCC appears to have a somewhat limited role in methamphetamine consumption and seeking following abstinence PMID: 23820928
20. The DCC expression by oligodendrocytes is required for the maintenance and stability of myelin in vivo, which is essential for proper signal conduction in the cenreal nervous system. PMID: 25031414
21. Reduced dcc in DA neurons increased mPFC DA innervation, including ectopic DA fibers that usually innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits leading to enhanced cognitive flexibility. PMID: 24346136
22. Netrin 1/Dcc/Unc5 chemotropism contributes to axonal confinement within the central nervous system. PMID: 24449837
23. this study reports that TUBB3, the most dynamic beta-tubulin isoform in neurons, directly interacts with the netrin receptor DCC, and that netrin-1 induces this interaction in primary neurons. PMID: 23641072
24. Data demonstrate that this horseshoe conformation of DCC is required for guidance-cue-mediated axonal attraction. Structure-based mutations that disrupt the DCC horseshoe indeed impair its function PMID: 23038776
25. DCC activation of Src is required for NMDAR-dependent long-term potentiation and certain forms of learning and memory. PMID: 23291093
26. DCC plays a crucial role in the formation of spinal neuronal circuitry coordinating left-right activities PMID: 22521513
27. DCC interaction with sytx1 is required for axonal guidance of migrating neurons from the lower rhombic lip. PMID: 22946563
28. In pre B-cell leukemia transcription factor 1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer, is down-regulated. PMID: 22748019
29. DCC promotes movement of Myo X along basal actin filaments and enhances Myo-X-mediated basal filopodium elongation. PMID: 22349703
30. results demonstrate that DCC functions as a tumour suppressor via its ability to trigger tumour cell apoptosis PMID: 22158121
31. data support the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells PMID: 22358843
32. DCC is a convergent receptor for netrin and draxin in axon growth and guidance. PMID: 21957262
33. Our results implicate DCC-mediated netrin-1 signaling in the establishment of medial prefrontal cortex dopamine circuitry during puberty. PMID: 21653843
34. DCC is a key regulator for the survival of specific types of neurons during retinal development and that the DCC-P3 domain is essential for this developing event. PMID: 20875817
35. DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons. PMID: 20493932
36. the DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism has a role in netrin-1 prevention of ischemia/reperfusion-induced myocardial infarction PMID: 20004665
37. Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems. PMID: 20628609
38. these results demonstrate that the DCC netrin-1 receptor, a protein traditionally known for its role in organizing brain development, plays a critical function in adult brain plasticity, possibly via orchestration of neuronal circuitry reorganization. PMID: 20345916
39. these findings show that the 'protective' dcc phenotype has a post-pubertal emergence and indicate that DCC may play a role in the normal maturation of the mesocorticolimbic dopamine system PMID: 19788579
40. Submucosal and pancreatic ganglia were absent at E12.5, E15, and P0 in transgenic mice lacking DCC. PMID: 12798294
41. DCC performs dual roles both as a cell surface receptor that modulates intracellular signaling pathways and as a transcriptional coactivator that relies on gamma-secretase-dependent production and nuclear translocation of the cytoplasmic domain. PMID: 12840034
42. We propose that DCC is regulated by tyrosine phosphorylation and that Fyn is essential for the response of axons to Netrin-1. PMID: 15557120
43. Significant DCC-immunoreactivity was detected in midbrain, where it was localized to ventrally displaced A9 dopamine neurons in the substantia nigra, and ventromedial A10 dopamine neurons predominantly situated in and around the interfascicular nucleus. PMID: 15730872
44. key molecule required for ventral migration of early-born neurons PMID: 15788454
45. Ligand-mediated down-regulation of Deleted in colorectal cancer might participate in loss of netrin-responsiveness in developing nervous system. PMID: 16181408
46. The data of this study show that a functional netrin-DCC signaling system is required for establishing proper VCN axonal projections in the auditory brainstem. PMID: 17701984
47. This study found that reduced DCC diminishes the rewarding and behavioural-activating effects of amphetamine and protects against amphetamine-induced deficits in sensorimotor gating. And layer V medial prefrontal cortex pyramidal neurones PMID: 18005074
48. Results demonstrate that DCC is a key regulator of tangential migration of locus coeruleus neurons during the embryonic development. PMID: 18771734

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KEGG: mmu:13176

STRING: 10090.ENSMUSP00000110593

UniGene: Mm.167882