Recombinant Mouse TNF receptor-associated factor 3 (Traf3)

1. A TRAF3-NIK axis differentially regulates viral DNA vs RNA pathways in innate immune signaling. PMID: 30018345
2. TRAF3 promotes T cell activation by regulating localization and functions of Csk and PTPN22. PMID: 28522807
3. osteoclast-targeted antagomir-214-3p delivery could recover the TRAF3 protein expression and attenuate the development of osteolytic bone metastasis. PMID: 28071724
4. These results indicate that TRAF3 deficiency suffices to metabolically reprogram B cells, a finding that improves our understanding of the role of TRAF3 as a tumor suppressor, and suggests potential therapeutic strategies. PMID: 27752131
5. Depletion of LAP1 during early embryonic myogenesis leads to growth retardation and premature death. PMID: 27798115
6. In B lymphocytes, TNFR-associated factor 3 inhibits signaling by TNFR superfamily receptors, Toll-like receptors, and interleukin-6R. In T lymphocytes, TNFR-associated factor 3 is required for normal signaling by the T cell antigen receptor, while inhibiting signaling by the interleukin-2 receptor. Cytoplasmic TNFR -associated factor 3 restrains nuclear factor-kappaB2 activation in both T and B cells. Review. PMID: 27154354
7. TRAF3 may likely induce apoptosis and resistance to proliferation and may be a new target to inhibit the cyst formation in polycystic kidney disease by regulating the NF-kappaB signaling pathway Bcl-2 and Bcl-xl activity. PMID: 28185403
8. this study shows that TRAF3 ubiquitination triggers expulsion of intracellular bacteria by exocyst complex PMID: 27438768
9. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors PMID: 28219902
10. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (TRIF), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 and TRIF. PMID: 28049150
11. These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3. PMID: 27377744
12. Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3. PMID: 26928339
13. findings identify TRAF3 and PTPN22 as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 in the regulation of plasma cell differentiation PMID: 26329582
14. TRAF3 expressed in myeloid cells regulates immune responses in myeloid cells and acts to inhibit inflammation and tumor development in mice. PMID: 25422508
15. The MYSM1 SWIRM domain interacts with TRAF3 to terminate PRR pathways for pro-inflammatory and type I interferon responses. PMID: 26474655
16. Data show that the degradation of TNF receptor-associated factor 3 (TRAF3) and TNF receptor-associated Ffactor 6 (TRAF6) was accelerated in ubiquitin-specific protease 25 knockout (USP25-/-) cells after viral infection. PMID: 26305951
17. Maternal diabetes and high glucose negatively regulate miR-322 through oxidative stress. miR-322 interacts with the 3'-UTR of TRAF3 and represses its translation. PMID: 25516495
18. These results indicate that the involvement of TRAF3 in IL-15 mediated signaling to T cells plays a previously unappreciated and critical role in CD8+ central memory T cells regulation and maintenance. PMID: 25010048
19. TRAF3 is a central regulator of ischemic pathways, including nuclear factor kappaB, Rac-1, and c-Jun kinase signaling, via its interaction with and activation of TAK1. PMID: 26269654
20. Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a positive regulator of pathological cardiac hypertrophy in mice and humans. PMID: 26034202
21. In obesity progression, myeloid TRAF3 functionally switches its activity from anti-inflammatory to proinflammatory modes, thereby coupling overnutrition to metabolic inflammation, insulin resistance, and metabolic disease. PMID: 25628422
22. Data show that docking protein 3 (DOK3) plays a role in TLR3 signaling by enabling TNFR-associated factor (TRAF) 3/TANK-binding kinase (TBK) 1 binding and facilitating TBK1 and IFN regulatory factor 3 activation and the induction of IFN-beta production. PMID: 24929003
23. TRAF3 is a mediator of Treg cell function in the regulation of antibody responses and plays a role in mediating ICOS expression in Treg cells. PMID: 24378539
24. Autophagic/lysosomal degradation of TRAF3 is an important step in RANKL-induced NF-kappaB activation in osteoclast precursors. PMID: 24316970
25. TRAF3 plays a central role in regulation of medullary thymic epithelial cells by imposing requirements for T cell cross-talk. PMID: 24324158
26. Data from knockout mice suggest that Traf3 and Tlr2 (toll-like receptor 2) are involved in innate immunity; via selective up-regulation of Traf3, macrophages can be primed with TLR2 ligands to increase virus-mediated interferon induction. PMID: 23853595
27. Defective T-bet up-regulation occurring during the stage 1 to stage 2 transition results from reduced TCR signaling in TRAF3(-/-) iNKT cells. PMID: 23650438
28. Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 degradation PMID: 23603814
29. In vitro and cellular experiments showed that forms of TRAF5 with mutation of the corresponding residues to those of TRAF3 had TRAF3-like antiviral activity. PMID: 23150880
30. Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30alpha in a TRAF3-dependent manner. PMID: 23220069
31. establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-kappaB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3 PMID: 23334419
32. using B lymphoma cells derived from B-TRAF3 -/- mice as model systems, we demonstarted that oridonin and NF-kB2 shRNAs have therapeutic potential PMID: 22033491
33. S-glutathionylation of a conserved cysteine residue of TRAF3 and TRAF6 is important for ROS-dependent activation of innate immune pathways in herpes simplex virus infection PMID: 21949653
34. Given the varied roles played by TRAF3 in immune cells, an important knowledge gap includes the distinct functions of TRAF3 in Toll-like receptor signaling to B cells. PMID: 21971520
35. TRAF3 markedly inhibited IL-17-induced expression of inflammatory cytokine and chemokine genes in vivo and consequently delayed the onset and greatly reduced the incidence and severity of experimental autoimmune encephalomyelitis (EAE). PMID: 21078888
36. the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase PMID: 20348096
37. Data show that TRIF-dependent signaling triggered noncanonical TRAF3 self-ubiquitination that activated the interferon response. PMID: 19898473
38. LMP1 signaling was markedly defective in TRAF3-/- B cells. PMID: 14981114
39. TRAF3 mediates carboxyl-terminal activating region 1 (CTAR1) of Epstein Barr virus-encoded oncoprotein latent membrane protein 1 signaling by directly interacting with CTAR1 through the first PQQAT amino acid motif. PMID: 15494504
40. cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several different TLRs PMID: 16306936
41. TRAF3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro-inflammatory cytokines PMID: 16306937
42. TRAF3 has a role in innate antiviral immunity [review] PMID: 16582590
43. TRAF3 play a critical role in negative regulation of noncanonical NF-kappa B activity. PMID: 17015635
44. Both the RING finger domain activity and the specific binding of the TRAF domain to NF-kappa B-inducing kinase (NIK) protein are two critical components of TRAF3 suppression of NIK protein levels and the processing of p100 to p52. PMID: 17158868
45. TRAF3 is a critical regulator of peripheral B cell homeostasis and may be implicated in the regulation of peripheral self-tolerance induction. PMID: 17723217
46. TRAF3 potently suppresses canonical (p50-dependent) NF-kappaB activation and gene expression in vitro and in vivo PMID: 18292232
47. Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer. PMID: 19074733
48. c-Src enhances RIG-I-mediated signaling, acting at the level of TRAF3 PMID: 19419966

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KEGG: mmu:22031

STRING: 10090.ENSMUSP00000021706

UniGene: Mm.27431