Recombinant Rat Cyclic AMP-responsive element-binding protein 1(Creb1)

Code CSB-YP005947RA
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Source Yeast
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Code CSB-EP005947RA
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Source E.coli
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Code CSB-EP005947RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005947RA
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Source Baculovirus
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Code CSB-MP005947RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Creb1
Uniprot No. P15337
Alternative Names Creb1; Creb-1Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1
Species Rattus norvegicus (Rat)
Expression Region 1-341
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Gene References into Functions
  1. The MEK-ERK/p38-CREB/c-fos signaling pathway is involved in Kir channel inhibition-induced rat retinal Muller cell gliosis. PMID: 28469203
  2. Estradiol up-regulates Cav1.2alpha1C and ICa,L via plasma membrane ER and by activating Pi3K, Akt, and CREB signaling. The promoter regions of the CACNA1C gene (human-rabbit-rat) contain adjacent/overlapping binding sites for p-CREB and ERalpha, which suggests a synergistic regulation by these pathways. PMID: 29330129
  3. reveal that salicylate administration causes tinnitus symptoms and elevates Ca(2+)/CaMKII/CREB signaling pathway in auditory cortex cells. PMID: 29427172
  4. Forced swim stress (FS) prior to the complete Freund's adjuvant (CFA) injection enhanced the CFA-induced mechanical hypersensitivity and attenuated the increase in the expression of pCREB and Egr1 in the insular cortex (IC) and anterior cingulate cortex (ACC) of Sprague-Dawley rats. These findings suggested an FS-induced alteration of neuroplasticity in the IC and ACC following CFA injection. PMID: 28866293
  5. CREB overexpression in aged animals ameliorated the long-term memory deficits observed in control animals. PMID: 28051768
  6. Suggest that SIRT1/CREB/TORC1 might play an important mediating role in Al-induced long-term memory impairment. PMID: 28429887
  7. In the hippocampus of female offspring exposed to prenatal stress, levels of CREB are decreased along with impaired spatial learning and memory. PMID: 28236215
  8. Forced swim stress induced a significant increase in the expression of pCREB and DeltaFosB and the acetylation of histone H3 in the rostral ventromedial medulla, whereas the forced swim stress induced a significant increase only in the acetylation of histone H3 in the locus coeruleus. PMID: 27530066
  9. The binding mechanism of CREB1. PMID: 28666847
  10. Activation of the NR2A/NR2B/CaMKII/ERK-P/CREB-P signaling axis in mature control neurons, with global increases in H3K27ac to control dendritogenesis of hippocampal neurons. PMID: 28160495
  11. CREB activity is reduced in the basolateral amygdala promoted by both enriched environment and acute stress. PMID: 27815155
  12. Findings suggest that brain-derived neurotrophic factor and cAMP response element binding protein may belong to the same pathway and be involved in psychological stress response mechanisms, and protect the organism from stress induced, aversive processes leading to disease. PMID: 27132084
  13. The findings provide evidence that IP3R2 expression is transcriptionally regulated by cyclic AMP via CREB binding to CRE elements in its promoter. PMID: 28327356
  14. Simvastatin may protect the kidney from oleic acid induced oxidative stress by upregulating the antioxidant HO-1 via CREB. PMID: 26492285
  15. Study provides the first in vivo demonstration for a possible mechanism of ginsenoside Rg1 via regulating changes in the CREB-PKA-BDNF pathway within the rat amygdala PMID: 26926964
  16. miR-124 suppresses seizure activity and regulates CREB1 activity. (Review) PMID: 26996991
  17. NR6A1 modulates SPP1 expression via its binding with CREB protein in vascular smooth muscle cells. PMID: 26546462
  18. Electroacupuncture improved the learning and memory ability of rats following transient middle cerebral artery occlusion, and markedly activated the CREB signaling pathway. PMID: 26397995
  19. Unilateral antigen-induced arthritis caused bilateral up-regulation of phospho-CREB in lumbar DRG neurons. While inflammation and pain subsided within 21 days, the up-regulation of phospho-CREB still persisted on day 42. PMID: 26473326
  20. The NR2B-CREB-CRTC1 signaling pathway may play a crucial role in circadian rhythm of pain PMID: 26440419
  21. decreased activation of the CREB signaling pathway in pups was related to impairments of cognitive function caused by maternal subclinical hypothyroidism. PMID: 25193019
  22. Auditory cortex CREB was activated by phosphorylation in salicylate-treated rats. Phospho-CREB levels returned to normal levels 14 days after cessation of treatment or after GM1 administration. PMID: 26554229
  23. BDNF exon-specific transcripts are differentially expressed in brain regions during spontaneous morphine withdrawal in dependent rats and pCreb1 may be at least partially responsible for these alterations PMID: 25392083
  24. CREB is phosphorylated in immature cortical cells following activation of BDNF expression by GABA. PMID: 24965890
  25. Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala PMID: 24597568
  26. the photoperiod affects the diurnal expression of iNOS and activation of CREB in the hippocampus, which provide clues for the possible impact of circadian changes in hippocampal functions. PMID: 25687488
  27. CREB transcription factor(s) was necessary for the transcriptional activation of tyrosine hydroxylase gene by propionic acid. PMID: 25170769
  28. The activation of CaMKII-CREB pathway in retinal Muller cells by high glucose is dependent on intracellular free calcium. PMID: 22796763
  29. Knock-down of cAMP response element binding protein activity significantly reduced or abolished the cAMP-induced calcium response PMID: 25154887
  30. Stimulation of long-term potentiation results in an increase in the levels of CREB protein in hypothyroidism. PMID: 24277525
  31. Studied the effects of acupuncture stimulation at GV20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) in rat hippocampus. PMID: 25231482
  32. Homer 1b/c regulates CREB phosphorylation in the spinal cord during chronic inflammatory pain. PMID: 24316406
  33. The aim of the present study was to investigate the effects of ovariectomy and 17beta-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing factor (AIF) and Endonuclease-G (Endo-G) and CREB in hippocampus of the adult female rats. PMID: 24121025
  34. The results indicate that NMDAR1 and CREB are involved in the ocular dominance forming process and play a role in vision plasticity PMID: 23381906
  35. Baicalin preserves hippocampal CREB expression to improve chronic corticosterone-induced learning and memory deficits. PMID: 23749289
  36. suggest that mIndy is a CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes PMID: 24222346
  37. The expression of PKAca and p-CREB protein levels were higher in the bone cancer pain rats. PMID: 23950594
  38. negative regulation of CREB activity by endogenous CaMKIIdelta-dependent CREB-Ser(142) phosphorylation and suggest a potential mechanism for CaMKIIdelta/CREB signaling in modulating proliferation and migration in VSM cells. PMID: 24106266
  39. Data suggest that Creb1 is involved in regulation of Sertoli cell function; CREB1 phosphorylation in cultured Sertoli cells appears to be up-regulated by FGF2 (basic fibroblast growth factor) or interleukin-1beta. PMID: 22932066
  40. BDNF plays a major role in enriched environment mediated neuroprotection and it effectively prevented neurodegeneration by activating PI3K/AKT pathway resulting in GSK3beta inactivation and CREB activation. PMID: 23704876
  41. CREB is a negative regulator of myoblast differentiation and regulates myostatin gene expression of calcium-dependent signaling pathways induced by IGF-1 PMID: 24064350
  42. Endogenous CREB activity in the amygdala may set a critical threshold for plasticity during memory formation. PMID: 24062441
  43. Repressed expression of miR-181a is involved in IGF-1-mediated up-regulation of CREB1 in vivo and in vitro PMID: 23865718
  44. RCAN1 induced the expression of the CREB target gene, Bcl-2. PMID: 23150431
  45. Sirt1 intercepts the cAMP pathway by suppressing CREB transcriptional activation, resulting in decreased growth hormone synthesis PMID: 23292070
  46. Chronic expression of dominant-negative CREB impairs memory for hippocampus-dependent tasks.Lentivirus expressing mCREB can be used to effectively alter CREB function within the hippocampus. PMID: 23110949
  47. Sleep deprivation reduced pCREB expression in the central nucleus compared to control or sleep recovered PMID: 22974552
  48. CREB phosphorylation is modulated by melatonin in pancreatic insuloma beta cells. PMID: 22616931
  49. Data suggest that diet (here, chronic caffeine intake) can contribute to cognitive processes in hippocampus; regardless of age, caffeine intake increases expression of CREB and proBDNF (brain-derived neurotrophic factor, precursor). PMID: 22841916
  50. Hippocampal glucocorticoid receptors involved in the formation of long-term inhibitory avoidance memory are coupled to the activation of CREB and CaMKIIalpha. PMID: 23160045

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Subcellular Location Nucleus.
Protein Families BZIP family
Database Links

KEGG: rno:81646

STRING: 10116.ENSRNOP00000018326

UniGene: Rn.90061


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