Leave a Message or Start an on-line Chat|
CD47, also known as integrin-associated protein, is a cell surface ligand expressed in low amounts by nearly all cells of the body. It plays an important role in numerous immunological responses as well as autoimmunity by providing a powerful "don't eat me" signal to prevent phagocytosis. CD47 is also indispensable for other cellular functions including proliferation, phagocytosis, apoptosis, adhesion, migration, immune homeostasis, and inhibition of NO signal transduction. CD47 is overexpressed in many hematological malignancies, and its association with SIRP on phagocytic cells inhibits cancer cells from being phagocytosed. CD47 overexpression is frequently linked to poor clinical outcomes.
The recombinant CD47 antibody is a monoclonal antibody made in vitro using the CD47 antibody genes that are typically expressed from a plasmid in a stable mammalian cell line. The genes coding for the CD47 antibody will ultimately assemble into a fully functional antibody after translation. The synthesized antibody is the recombinant antibody against CD47. It underwent purification using Affinity-chromatography. This recombinant CD47 antibody is suitable for use in the ELISA, WB, IHC, IF to detect the CD47 protein from Human.There are currently no reviews for this product.