CD47 Research Reagents

CD47, also known as integrin associated protein (IAP) is a transmembrane protein encoded by the CD47 gene in human.It belongs to the immunoglobulin superfamily[5] and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). It has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Moreover, this protein plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). It can bind to SIRPA as a receptor to prevent maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Most Popular Product:

Recombinant Human Leukocyte surface antigen CD47(CD47),partial (Active) (CSB-MP004940HU)

Validated Data

High Purity Validated by SDS-PAGE

Greater than 93% as determined by SDS-PAGE.

Excellent Bioactivity Validated by Functional ELISA

Immobilized SIRPA (CSB-MP021334HU) at 2 μg/ml can bind human CD47, the EC₅₀ of human CD47 protein is 65.91-82.42 ng/ml.

High Bioactivity Validated by LSPR

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag with an affinity constant of 19.1 nM as detected by LSPR Assay.