CLDN4 Antibody

Datasheet
Code CSB-RA005506A0HU
Size US$350
Uniprot No. O14493
Protocols ELISA Protocol
Immunogen A synthesized peptide derived from human CLDN4
Species Reactivity Human
Tested Applications ELISA
Relevance Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Claudin-4, Clostridium perfringens enterotoxin receptor, CLDN4, CPER, CPETR1, WBSCR8
Immunogen Species Human
Research Area Signal Transduction
Gene Names CLDN4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Involvement in disease CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Subcellular Location Cell junction, tight junction, Cell membrane, Multi-pass membrane protein
Protein Families Claudin family
Database Links

HGNC: 2046

OMIM: 602909

KEGG: hsa:1364

STRING: 9606.ENSP00000342445

UniGene: Hs.647036

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