|Have Questions?||Leave a Message or Start an on-line Chat|
The recombinant CLDN4 antibody was prepared by obtaining the antibody genes, cloning the genes into a plasma vector to construct vector clone, transfecting the vector clone into a mammalian cell line for transient expression, and purifying the antibody by affinity-chromatography. This recombinant CLDN4 antibody has been verified to detect the CLDN4 protein from Human in the ELISA.
CLDN4 is a transmembrane protein involved in tight junction formation and function. It is responsible for the maintenance of epithelial cell polarity and the establishment of the intercellular barrier. CLDN4 is a well-known differentiation marker, and its presence is regarded to indicate a more epithelial phenotype. Decreased expression of CLDN4 correlates with EMT. High expression of CLDN4 has been reported in multiple human malignancies, including ovarian, renal, and bladder cancer.
There are currently no reviews for this product.