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CUSABIO's product CSB-RA008836A0HU is a FOXO3 recombinant monoclonal antibody. Clone the gene fragment encoding human FOXO3 protein into the expression vector and subsequently transfect clones into the cell line for in vitro expression. This FOXO3 recombinant antibody can detect the endogenous content of the human FOXO3 protein. It is purified by the affinity chromatography method. And it has passed through quality testing in ELISA, WB, IHC, and IF applications.
As a central transcription factor, FOXO3 mediates multiple physiological and pathological processes by inducing transcription of target genes involved in apoptosis, proliferation, cell cycle progression, survival, and DNA damage. FOXO3 has been consistently linked to longevity in vivo models. It also participates in regulating the autophagy process in muscle and in cancer cells. The deregulation of FOXO3 expression or activity can result in various diseases, particularly cancer.
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