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The ITK recombinant monoclonal antibody is a valuable tool for the detection of human ITK protein in ELISA and IHC applications. This antibody is developed using recombinant DNA technology, wherein the gene that codes for the ITK monoclonal antibody is synthesized after sequencing the cDNA of the hybridomas that produce the ITK antibody. These hybridomas are obtained by fusing myeloma cells with B cells isolated from animals that have been immunized with a synthesized peptide derived from human ITK. The synthesized gene is then cloned into a vector. The ITK antibody gene-containing vector is transfected into cells for cultivation. The resulting ITK recombinant monoclonal antibody is purified using affinity chromatography from the cell culture supernatant.
The ITK is a protein that plays an important role in T-cell activation and signaling. When a T-cell receptor (TCR) on the surface of a T-cell recognizes an antigen presented by an antigen-presenting cell (APC), ITK is activated and triggers a signaling cascade that leads to T-cell activation and proliferation. ITK is also involved in signaling downstream of chemokine receptors and integrins, which are important for T-cell migration and adhesion.
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