Code | CSB-RA018710A560phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The coding sequence for the phospho-PRKCZ (T560) monoclonal antibody (isolated by immunizing animals with the human pT560-PRKCZ) was cloned into the plasmids and then transfected into cell lines for in vitro expression. The product underwent affinity-chromatography-mediated purification to get the phospho-PRKCZ (T560) recombinant monoclonal antibody. This anti-pT560-PRKCZ antibody is a rabbit IgG. It is suitable for the detection of human PRKCZ phosphorylated at Thr 560 residue. And it can be used in ELISA and WB applications.
PRKCZ is an atypical protein kinase C isoform that regulates a variety of signaling events, including cell proliferation, cell survival, and cell motility, all of which are critical for cancer formation and progression. PRKCZ is involved in a number of signaling pathways, including the activation of the ERK/MAPK cascade, the p70 ribosomal S6 kinase signaling cascade, the transcription factor NF-B, and cell polarity regulation. Kelly K. Y. Seto et al. discovered that PRKCZ is a promising regulatory component of the IGF1R and ITGB3 pathways, implying that it could be important in ovarian tumorigenesis.
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