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| Code | CSB-RA618017A255phHU |
| Size | US$350 |
| Uniprot No. | Q15796 |
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| Protocols | ELISA Protocol Immunofluorescence (IF) Protocol |
| Immunogen | A synthesized peptide derived from Human Phospho-SMAD2 (S255) |
| Species Reactivity | Human |
| Tested Applications | ELISA, IF; Recommended dilution: IF:1:20-1:200 |
| Relevance | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Affinity-chromatography |
| Isotype | Rabbit IgG |
| Clonality | Monoclonal |
| Alias | Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2 |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Signal Transduction |
| Gene Names | SMAD2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Subcellular Location | Cytoplasm, Nucleus |
| Protein Families | Dwarfin/SMAD family |
| Tissue Specificity | Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. |
| Database Links |
HGNC: 6768 OMIM: 601366 KEGG: hsa:4087 STRING: 9606.ENSP00000262160 UniGene: Hs.12253 |
| Pathway |
Hippo signaling pathway
TGF-beta signaling pathway Adherens junction Cell cycle Cellular senescence Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway FoxO signaling pathway Endocytosis |
SMAD2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021787GA01HU | SMAD2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA783890 | Phospho-SMAD2 (Ser467) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA084599 | Phospho-SMAD2 (Thr220) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA047751 | SMAD2 (Ab-467) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA093530 | SMAD2 (Ab-220) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA788461 | Phospho-SMAD2 (Ser250) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA139936 | Phospho-SMAD2 (Ser465) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA594584 | SMAD2 (Ab-220) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA981649 | SMAD2 (Ab-465) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000675 | Phospho-SMAD2 (S467) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA004106 | SMAD2 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA004107 | SMAD2 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA004109 | SMAD2 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA009933 | Phospho-SMAD2 (S250) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA009945 | Phospho-SMAD2 (S465) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA009946 | Phospho-SMAD2 (T220) Antibody | Human,Mouse,Rat | IHC,IF,ELISA |
| CSB-PA009952 | SMAD2 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA009953 | SMAD2 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA080253 | SMAD2 Antibody | Human | WB |
| CSB-RA618017A250phHU | Phospho-SMAD2 (S250) Antibody | Human | ELISA, WB |
SMAD2 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA15557A0Rb | SMAD2 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA15557B0Rb | SMAD2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA15557C0Rb | SMAD2 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA15557D0Rb | SMAD2 Antibody, Biotin conjugated | Human | ELISA |
SMAD2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP618017HU CSB-BP618017HU CSB-MP618017HU |
Recombinant Human Mothers against decapentaplegic homolog 2(SMAD2) | Yeast Baculovirus Mammalian cell |
| CSB-EP618017HUa2 | Recombinant Human Mothers against decapentaplegic homolog 2(SMAD2) | E.coli |
SMAD2 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E15763h | Human Mothers Against Decapentaplegic Homolog 2(SMAD2) ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 7.8 pg/mL |
2-hydroxyisobutyryl-HIST1H4A (K5) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
